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Gallic acid conjugated with gold nanoparticles: antibacterial activity and mechanism of action on foodborne pathogens

Overview of attention for article published in International Journal of Nanomedicine, July 2016
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Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
32 Mendeley
Title
Gallic acid conjugated with gold nanoparticles: antibacterial activity and mechanism of action on foodborne pathogens
Published in
International Journal of Nanomedicine, July 2016
DOI 10.2147/ijn.s109795
Pubmed ID
Authors

Jureerut Daduang, Sompong Klaynongsruang, Chanvit Leelayuwat, Temduang Limpaiboon, Aroonlug Lulitanond, Patcharee Boonsiri, Sirinart Srichan, Siriwat Soontaranon, Supagorn Rugmai, Narintorn Rattanata

Abstract

Foodborne pathogens, including Plesiomonas shigelloides and Shigella flexneri B, are the major cause of diarrheal endemics worldwide. Antibiotic drug resistance is increasing. Therefore, bioactive compounds with antibacterial activity, such as gallic acid (GA), are needed. Gold nanoparticles (AuNPs) are used as drug delivery agents. This study aimed to conjugate and characterize AuNP-GA and to evaluate the antibacterial activity. AuNP was conjugated with GA, and the core-shell structures were characterized by small-angle X-ray scattering and transmission electron microscopy. Antibacterial activity of AuNP-GA against P. shigelloides and S. flexneri B was evaluated by well diffusion method. AuNP-GA bactericidal mechanism was elucidated by Fourier transform infrared microspectroscopic analysis. The results of small-angle X-ray scattering showed that AuNP-GA conjugation was successful. Antibacterial activity of GA against both bacteria was improved by conjugation with AuNP because the minimum inhibitory concentration value of AuNP-GA was significantly decreased (P<0.0001) compared to that of GA. Fourier transform infrared analysis revealed that AuNP-GA resulted in alterations of lipids, proteins, and nucleic acids at the bacterial cell membrane. Our findings show that AuNP-GA has potential for further application in biomedical sciences.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 19%
Student > Ph. D. Student 5 16%
Student > Master 5 16%
Student > Bachelor 5 16%
Student > Doctoral Student 3 9%
Other 4 13%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 22%
Chemistry 5 16%
Biochemistry, Genetics and Molecular Biology 3 9%
Materials Science 2 6%
Medicine and Dentistry 2 6%
Other 6 19%
Unknown 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#6,514,494
of 11,379,716 outputs
Outputs from International Journal of Nanomedicine
#845
of 2,262 outputs
Outputs of similar age
#123,190
of 265,579 outputs
Outputs of similar age from International Journal of Nanomedicine
#50
of 122 outputs
Altmetric has tracked 11,379,716 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,262 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.