"This study showed that hydroxyurea reduced levels of STAT3 phosphorylation and, in effect, decreased endothelial membrane P-selectin expression." #LongCovid https://t.co/zSmEyPgDL7

https://t.co/xsBQLVkQK9 "The antithrombotic effect of hydroxyurea may not be due only to a lowering of blood cell counts."

https://t.co/xsBQLVkQK9 "This study showed that hydroxyurea reduced levels of STAT3 phosphorylation and, in effect, decreased endothelial membrane P-selectin expression." #LongCovid

https://t.co/xsBQLVkQK9 "also a consequence of STAT3 phosphorylation, that can be reversed by hydroxyurea or a P-selectin-blocking antibody."

https://t.co/xsBQLVkQK9 "In a recent investigation using human and mice endothelial cells overexpressing JAK2V617F, the authors showed that JAK2V617F-expressing endothelial cells promote thromboses through the induction of endothelial P-selectin expressio

https://t.co/xsBQLVkQK9 "JAK2 is also present in endothelial cells." #MECFS #LongCovid

P-Selectin Blockade in the Treatment of Painful Vaso-Occlusive Crises in Sickle Cell Disease: A Spotlight on Crizanlizumab https://t.co/xsBQLVkQK9

Very intriguing, and related to work by @Drdragonfraser’s group.

@cjmaddison @BhupeshPrusty @scotjess3 Microvascular vaso-occlusion seen in sickle cell anemia patients (P-selectin plays a key role) is treated with hydroxyurea and crizanlizumab; https://t.co/xwJE0QwRRz

P-Selectin Blockade in the Treatment of Painful Vaso-Occlusive Crises in Sickle Cell Disease: A Spotlight on Crizanlizumab https://t.co/ZTxPnLdXeL