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Efficacy, safety, and tolerability of fentanyl pectin nasal spray in patients with breakthrough cancer pain

Overview of attention for article published in Journal of Pain Research, August 2016
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Mentioned by

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2 tweeters

Citations

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4 Dimensions

Readers on

mendeley
18 Mendeley
Title
Efficacy, safety, and tolerability of fentanyl pectin nasal spray in patients with breakthrough cancer pain
Published in
Journal of Pain Research, August 2016
DOI 10.2147/jpr.s106177
Pubmed ID
Authors

Michael Ueberall, Stefan Lorenzl, Eberhard Lux, Voltz Raymond, Michael Perelman, Ueberall, Michael A, Lorenzl, Stefan, Lux, Eberhard A, Voltz, Raymond, Perelman, Michael

Abstract

Assessment of analgesic effectiveness, safety, and tolerability of fentanyl pectin nasal spray (FPNS) in the treatment of breakthrough cancer pain (BTcP) in routine clinical practice. A prospective, open-label, noninterventional study (4-week observation period, 3 month follow-up) of opioid-tolerant adults with BTcP in 41 pain and palliative care centers in Germany. Standardized BTcP questionnaires and patient diaries were used. Evaluation was made of patient-reported outcomes with respect to "time to first effect", "time to maximum effect", BTcP relief, as well as changes in BTcP-related impairment of daily life activities, quality-of-life restrictions, and health care resource utilization. A total of 235 patients were recruited of whom 220 completed all questionnaires and reported on 1,569 BTcP episodes. Patients reported a significant reduction of maximum BTcP intensity (11-stage numerical rating scale [0= no pain, 10= worst pain conceivable]) with FPNS (mean ± standard deviation = 2.8±2.3) compared with either that reported at baseline (8.5±1.5), experienced immediately before FPNS application (7.4±1.7), or that achieved with previous BTcP medication (6.0±2.0; P<0.001 for each comparison). In 12.3% of BTcP episodes, onset of pain relief occurred ≤2 minutes and in 48.4% ≤5 minutes; maximum effects were reported within 10 minutes for 37.9% and within 15 minutes for 79.4%. By the end of the study, there had been significant improvements versus baseline in BTcP-related daily life activities (28.3±16.9 vs 53.1±11.9), physical (35.9±8.4 vs 26.8±6.5), and mental quality of life (38.7±8.5 vs 29.9±7.9) (P<0.001 for each comparison vs baseline); in addition, health care resource utilization requirements directly related to BTcP were reduced by 67.5%. FPNS was well tolerated; seven patients (3.2%) experienced eight treatment-emergent adverse events of which none was serious. There were no indicators of misuse or abuse. FPNS provided rapid and highly effective BTcP relief in opioid-tolerant cancer patients with substantial improvements in daily functioning and quality of life. FPNS was well tolerated and associated with significant reductions in health care resource utilization and nursing assistance.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 6%
Italy 1 6%
Unknown 16 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 28%
Student > Ph. D. Student 4 22%
Student > Master 2 11%
Student > Bachelor 2 11%
Professor 2 11%
Other 3 17%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Pharmacology, Toxicology and Pharmaceutical Science 3 17%
Nursing and Health Professions 2 11%
Unspecified 2 11%
Social Sciences 2 11%
Other 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2016.
All research outputs
#6,669,973
of 8,756,523 outputs
Outputs from Journal of Pain Research
#470
of 561 outputs
Outputs of similar age
#181,859
of 257,155 outputs
Outputs of similar age from Journal of Pain Research
#21
of 23 outputs
Altmetric has tracked 8,756,523 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 561 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.7. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,155 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.