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Antipsychotic agents: efficacy and safety in schizophrenia

Overview of attention for article published in Drug, Healthcare and Patient Safety, November 2012
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  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
58 Mendeley
citeulike
1 CiteULike
Title
Antipsychotic agents: efficacy and safety in schizophrenia
Published in
Drug, Healthcare and Patient Safety, November 2012
DOI 10.2147/dhps.s37429
Pubmed ID
Authors

Eduardo Ponde de Sena, Araújo, Irismar de Oliveira, Mario Juruena

Abstract

Antipsychotics have provided a great improvement in the management of people with schizophrenia. The first generation antipsychotics could establish the possibility of managing many psychotic subjects in an outpatient setting. With the advent of the second (SGA) and third generation antipsychotics (TGA), other psychiatric disorders such as bipolar depression, bipolar mania, autism, and major depressive disorder have now been approved for the use of these drugs for their treatment. Also, the administration of more specific assessment tools has allowed for better delineation of the repercussions of these drugs on symptoms and the quality of life of patients who use antipsychotic agents. In general, the SGA share similar mechanisms of action to achieve these results: dopamine-2 receptor antagonism plus serotonin-2A receptor antagonism. The TGA (eg, aripiprazole) have partial agonist activity at the dopamine-2 receptor site, and are also called dopaminergic stabilizers. The pharmacological profile of SGA and TGA may provide better efficacy against negative symptoms, and are less likely to produce extrapyramidal symptoms; however, the SGA and TGA are associated with many other adverse events. The clinician has to balance the risks and benefits of these medications when choosing an antipsychotic for an individual patient.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 2%
Brazil 1 2%
Turkey 1 2%
Unknown 55 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 17%
Student > Master 10 17%
Student > Ph. D. Student 7 12%
Researcher 7 12%
Student > Doctoral Student 5 9%
Other 19 33%
Readers by discipline Count As %
Medicine and Dentistry 18 31%
Unspecified 11 19%
Psychology 10 17%
Agricultural and Biological Sciences 6 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2013.
All research outputs
#2,928,013
of 4,507,280 outputs
Outputs from Drug, Healthcare and Patient Safety
#44
of 65 outputs
Outputs of similar age
#177,456
of 280,201 outputs
Outputs of similar age from Drug, Healthcare and Patient Safety
#4
of 5 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 65 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,201 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.