https://t.co/5JidC8Hen0 To assess the association between subtypes and exacerbation risk, we collected the three gene signatures associated with exacerbation risk from previous studies.

https://t.co/5JidC8Hen0 First, 442 FEV1-related genes and 1638 FEV1/FVC-related genes were preliminarily identified from 2752 metabolism-related genes by univariate linear regression.

https://t.co/5JidC8pDvs We applied a method with two steps inspired by the ideas of a hybrid approach to select genes associated with FEV1 or FEV1/FVC.

https://t.co/5JidC8Hen0 Metabolism-Associated Molecular Subtypes of COPD | COPD - Dove Medical Press.