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Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review

Overview of attention for article published in International Journal of Nanomedicine, December 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

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2 X users
patent
4 patents

Citations

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97 Dimensions

Readers on

mendeley
115 Mendeley
Title
Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review
Published in
International Journal of Nanomedicine, December 2012
DOI 10.2147/ijn.s38330
Pubmed ID
Authors

Mohammad Ariful Islam, Jannatul Firdous, Yun-Jaie Choi, Cheol-Heui Yun, Chong-Su Cho

Abstract

Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemicals, drugs, antigenic molecules as a vaccine candidate, and microorganisms. Therefore, chitosan together with the advance of nanotechnology can be effectively applied as a carrier system for vaccine delivery. In fact, chitosan microspheres have been studied as a promising carrier system for mucosal vaccination, especially via the oral and nasal route to induce enhanced immune responses. Moreover, the thiolated form of chitosan is of considerable interest due to its improved mucoadhesivity, permeability, stability, and controlled/extended release profile. This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 2 2%
Unknown 113 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 17%
Student > Ph. D. Student 18 16%
Student > Master 16 14%
Student > Bachelor 12 10%
Student > Doctoral Student 7 6%
Other 18 16%
Unknown 25 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 18%
Pharmacology, Toxicology and Pharmaceutical Science 18 16%
Biochemistry, Genetics and Molecular Biology 9 8%
Chemistry 8 7%
Medicine and Dentistry 7 6%
Other 22 19%
Unknown 30 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2020.
All research outputs
#3,415,350
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#200
of 4,123 outputs
Outputs of similar age
#31,874
of 285,750 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 57 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.