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Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review

Overview of attention for article published in International Journal of Nanomedicine, December 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

twitter
2 tweeters
patent
4 patents

Citations

dimensions_citation
76 Dimensions

Readers on

mendeley
102 Mendeley
Title
Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review
Published in
International Journal of Nanomedicine, December 2012
DOI 10.2147/ijn.s38330
Pubmed ID
Authors

Chong-Su Cho, Islam, Firdous, Choi, Yun

Abstract

Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemicals, drugs, antigenic molecules as a vaccine candidate, and microorganisms. Therefore, chitosan together with the advance of nanotechnology can be effectively applied as a carrier system for vaccine delivery. In fact, chitosan microspheres have been studied as a promising carrier system for mucosal vaccination, especially via the oral and nasal route to induce enhanced immune responses. Moreover, the thiolated form of chitosan is of considerable interest due to its improved mucoadhesivity, permeability, stability, and controlled/extended release profile. This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 2 2%
Unknown 100 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 17%
Student > Master 16 16%
Researcher 16 16%
Student > Bachelor 13 13%
Student > Doctoral Student 5 5%
Other 20 20%
Unknown 15 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 20%
Pharmacology, Toxicology and Pharmaceutical Science 17 17%
Chemistry 9 9%
Medicine and Dentistry 7 7%
Biochemistry, Genetics and Molecular Biology 7 7%
Other 20 20%
Unknown 22 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2020.
All research outputs
#2,298,129
of 18,217,940 outputs
Outputs from International Journal of Nanomedicine
#112
of 3,286 outputs
Outputs of similar age
#31,802
of 266,531 outputs
Outputs of similar age from International Journal of Nanomedicine
#2
of 53 outputs
Altmetric has tracked 18,217,940 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,286 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,531 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.