| Title |
Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain
|
|---|---|
| Published in |
Drug Design, Development and Therapy, January 2013
|
| DOI | 10.2147/dddt.s37330 |
| Pubmed ID | |
| Authors |
Beniamino Palmieri, Valentina Rottigni, Tommaso Iannitti |
| Abstract |
Hyaluronic acid has been extensively used for treatment of knee osteoarthritis due to its anti-inflammatory properties and its ability to act as a synovial lubricant. Furthermore, it has found application in combination with other drugs in the dermatological field and in pre-clinical studies in animal models of osteoarthritis. Experimental evidence suggests that a combination of this macromolecule with other drugs may act as a slow-release depot. However, to date, to the best of our knowledge, no one has tested local intra-articular delivery of highly cross-linked hyaluronic acid combined with bisphosphonate or nonsteroidal anti-inflammatory drugs for management of knee osteoarthritis pain in the clinical setting. The aim of the present randomized double-blind study was to investigate, for the first time, the effect of a highly cross-linked hyaluronic acid, Variofill(®), alone or in combination with diclofenac sodium or sodium clodronate, for management of bilateral knee osteoarthritis-related pain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Mexico | 1 | <1% |
| India | 1 | <1% |
| Unknown | 111 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 17% |
| Student > Bachelor | 19 | 17% |
| Researcher | 15 | 13% |
| Student > Ph. D. Student | 9 | 8% |
| Student > Postgraduate | 7 | 6% |
| Other | 20 | 17% |
| Unknown | 26 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 40% |
| Agricultural and Biological Sciences | 12 | 10% |
| Nursing and Health Professions | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Neuroscience | 3 | 3% |
| Other | 11 | 10% |
| Unknown | 33 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#8,039,503
of 25,584,565 outputs
Outputs from Drug Design, Development and Therapy
#541
of 2,254 outputs
Outputs of similar age
#80,305
of 289,948 outputs
Outputs of similar age from Drug Design, Development and Therapy
#6
of 16 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,254 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.