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Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain

Overview of attention for article published in Drug Design, Development and Therapy, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
85 Mendeley
Title
Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain
Published in
Drug Design, Development and Therapy, January 2013
DOI 10.2147/dddt.s37330
Pubmed ID
Authors

Tommaso Iannitti, Fistetto, Palmieri

Abstract

Hyaluronic acid has been extensively used for treatment of knee osteoarthritis due to its anti-inflammatory properties and its ability to act as a synovial lubricant. Furthermore, it has found application in combination with other drugs in the dermatological field and in pre-clinical studies in animal models of osteoarthritis. Experimental evidence suggests that a combination of this macromolecule with other drugs may act as a slow-release depot. However, to date, to the best of our knowledge, no one has tested local intra-articular delivery of highly cross-linked hyaluronic acid combined with bisphosphonate or nonsteroidal anti-inflammatory drugs for management of knee osteoarthritis pain in the clinical setting. The aim of the present randomized double-blind study was to investigate, for the first time, the effect of a highly cross-linked hyaluronic acid, Variofill(®), alone or in combination with diclofenac sodium or sodium clodronate, for management of bilateral knee osteoarthritis-related pain.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Spain 1 1%
Mexico 1 1%
India 1 1%
Unknown 81 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 19%
Student > Master 15 18%
Researcher 12 14%
Student > Ph. D. Student 8 9%
Other 7 8%
Other 19 22%
Unknown 8 9%
Readers by discipline Count As %
Medicine and Dentistry 37 44%
Agricultural and Biological Sciences 12 14%
Nursing and Health Professions 6 7%
Biochemistry, Genetics and Molecular Biology 3 4%
Chemistry 3 4%
Other 10 12%
Unknown 14 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#3,085,339
of 12,510,237 outputs
Outputs from Drug Design, Development and Therapy
#166
of 1,315 outputs
Outputs of similar age
#60,207
of 259,667 outputs
Outputs of similar age from Drug Design, Development and Therapy
#6
of 24 outputs
Altmetric has tracked 12,510,237 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,315 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,667 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.