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Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma

Overview of attention for article published in International Journal of Nanomedicine, September 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
48 Mendeley
Title
Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
Published in
International Journal of Nanomedicine, September 2016
DOI 10.2147/ijn.s108633
Pubmed ID
Authors

ZiLing Sun, Hui Li, Jian Tian, Anqing Wu, Jiamin Wang, Cuicui Ge

Abstract

Self-assembled nanoparticles of the natural polymer, silk fibroin (SF), are a very promising candidate in drug delivery due to their biocompatible and biodegradable properties. In this study, SF nanoparticles loaded with 5-fluorouracil (5-FU) and curcumin with size 217±0.4 nm and with a loading efficacy of 45% and 15% for 5-FU and curcumin, respectively, were prepared. The in vitro release effect of 5-FU and curcumin from nanoparticles was evaluated as ~100% and ~5%, respectively. It has been revealed that the application of such a nanodrug can increase the level of reactive oxygen species, which in turn induces apoptosis of cancer cells in vitro. Animal studies have shown that tumors could be noticeably reduced after being injected with the drug-entrapped nanoparticles. More apoptotic cells were found after 7 days of treatment with SF nanoparticles by a hematoxylin-eosin staining assay. These results demonstrate the future potential of nanoparticle-loaded binary drugs in the treatment of breast cancer.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Student > Master 10 21%
Student > Bachelor 9 19%
Researcher 4 8%
Student > Doctoral Student 2 4%
Other 4 8%
Unknown 8 17%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 10 21%
Biochemistry, Genetics and Molecular Biology 8 17%
Chemistry 5 10%
Materials Science 4 8%
Agricultural and Biological Sciences 4 8%
Other 5 10%
Unknown 12 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2016.
All research outputs
#6,249,405
of 11,227,973 outputs
Outputs from International Journal of Nanomedicine
#711
of 2,230 outputs
Outputs of similar age
#115,726
of 258,741 outputs
Outputs of similar age from International Journal of Nanomedicine
#34
of 139 outputs
Altmetric has tracked 11,227,973 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,230 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,741 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.