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Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

Overview of attention for article published in Drug Design, Development and Therapy, September 2016
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter
video
1 video uploader

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
16 Mendeley
Title
Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents
Published in
Drug Design, Development and Therapy, September 2016
DOI 10.2147/dddt.s108327
Pubmed ID
Authors

Lidia Moreira Lima, Gisele Zapata-Sudo, Isabelle Karine da Costa Nunes, Josenildo Segundo Chaves de Araujo, Jaqueline da Silva, Margarete Manhães Trachez, Tiago Fernandes da Silva, Filipe P. da Costa, Roberto Sudo, Eliezer Barreiro

Abstract

Neuropathy is a serious complication of diabetes that has a significant socioeconomic impact, since it frequently demands high levels of health care consumption and compromises labor productivity. Recently, LASSBio-1471 (3) was demonstrated to improve oral glucose tolerance, reduce blood glucose levels, and display an anti-neuropathy effect in a murine streptozotocin-induced diabetes model. In the present work, we describe the design, synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazone derivatives (referred to herein as compounds 4-9), which were designed by molecular modification based on the structure of the prototype LASSBio-1471 (3). Among the compounds tested, better plasma stability was observed with 4, 5, and 9 in comparison to compounds 6, 7, and 8. LASSBio-1773 (7), promoted not only hypoglycemic activity but also the reduction of thermal hyperalgesia and mechanical allodynia in a murine model of streptozotocin-induced diabetic neuropathic pain.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 13%
Other 2 13%
Student > Doctoral Student 2 13%
Professor 2 13%
Student > Bachelor 1 6%
Other 3 19%
Unknown 4 25%
Readers by discipline Count As %
Chemistry 6 38%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Physics and Astronomy 2 13%
Biochemistry, Genetics and Molecular Biology 1 6%
Nursing and Health Professions 1 6%
Other 0 0%
Unknown 4 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2016.
All research outputs
#6,348,644
of 8,366,012 outputs
Outputs from Drug Design, Development and Therapy
#566
of 1,055 outputs
Outputs of similar age
#178,099
of 252,579 outputs
Outputs of similar age from Drug Design, Development and Therapy
#29
of 68 outputs
Altmetric has tracked 8,366,012 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,055 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,579 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.