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Effective combination treatment of lung cancer cells by single vehicular delivery of siRNA and different kinds of anticancer drugs

Overview of attention for article published in International Journal of Nanomedicine, September 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
19 Mendeley
Title
Effective combination treatment of lung cancer cells by single vehicular delivery of siRNA and different kinds of anticancer drugs
Published in
International Journal of Nanomedicine, September 2016
DOI 10.2147/ijn.s107345
Pubmed ID
Authors

Jin-Ming Li, Yuanyuan Wang, Shanshan Xue, Jinghua Sun, Wei Zhang, Ping Hu, Liangnian Ji, Zongwan Mao

Abstract

In recent years, lung cancer has become one of the fastest growing cancers in the world. Thus, the development of efficient combination therapy to treat lung cancer has attracted significant attention in the cancer therapy field. In this article, we developed a single vehicle drug delivery system, based on quantum dot (QD) nanoparticles, to deliver small interfering RNA (siRNA; target Bcl-2) and different anticancer drugs (carboplatin, paclitaxel, and doxorubicin) simultaneously for treating A549 lung cancer cells efficiently by combination therapy. The QD nanoparticles were conjugated with l-arginine (l-Arg) and different kinds of hydroxypropyl-cyclodextrins (HP-α-CDs, HP-β-CDs, and HP-γ-CDs) on the surface to form the delivery nanocarriers (QD nanocarriers). They were able to not only bind and transport the siRNA through electrostatic interactions with l-Arg residues but also accommodate various disparate anticancer drugs using different HP-CD modifications. Compared with free drug treatments, the use of QD nanocarriers to deliver Bcl-2 siRNA and different anticancer drugs simultaneously exerted a threefold to fourfold increase in cytotoxicity in A549 cells, which greatly improved the treatment efficacy through combined action. Furthermore, the QD nanocarriers could be used as a probe for real-time imaging of the drug delivery and release because of their strong fluorescence properties. These findings indicate that multifunctional QD nanocarriers hold great promise as a powerful tool for combination therapy for lung cancer.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 21%
Student > Bachelor 3 16%
Unspecified 1 5%
Student > Doctoral Student 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 8 42%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 16%
Engineering 2 11%
Medicine and Dentistry 2 11%
Nursing and Health Professions 1 5%
Agricultural and Biological Sciences 1 5%
Other 3 16%
Unknown 7 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2016.
All research outputs
#3,917,688
of 9,113,123 outputs
Outputs from International Journal of Nanomedicine
#329
of 1,986 outputs
Outputs of similar age
#101,406
of 256,297 outputs
Outputs of similar age from International Journal of Nanomedicine
#22
of 127 outputs
Altmetric has tracked 9,113,123 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,986 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,297 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.