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Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles

Overview of attention for article published in International Journal of Nanomedicine, June 2012
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Title
Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles
Published in
International Journal of Nanomedicine, June 2012
DOI 10.2147/ijn.s30943
Pubmed ID
Authors

Yihui Deng, Zhao, Wang, Yan, Ma, Zang, She

Abstract

Surface modification of nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known as PEGylation, is regarded as a major breakthrough in the application of nanocarriers. However, PEGylated nanocarriers (including liposomes and polymeric nanoparticles) induce what is referred to as the "accelerated blood clearance (ABC) phenomenon" upon repeated injection and consequently they lose their sustained circulation characteristics. Despite this, the present authors are not aware of any reports of accelerated clearance due to repeated injection for PEGylated solid lipid nanoparticles (SLNs), another promising nanocarrier. This study investigated the pharmacokinetics of PEGylated SLNs upon repeated administration in mice; moreover, the impact of circulation time on the induction of the ABC phenomenon was studied in beagles for the first time. The ABC index, selected as the ratio of the area under the concentration-time curve from time 0 to the last measured concentration of a second injection to that of the first injection, was used to evaluate the extent of this phenomenon. Results showed that the PEGylated SLNs exhibited accelerated clearance from systemic circulation upon repeated injection, both in mice and in beagles, and the ratio for the different time intervals, which showed that the ABC index exhibited significant difference within 30 minutes following the second injection, was good enough to evaluate the magnitude of ABC. This ABC index indicated that the 10 mol% PEG SLNs with a suitable prolonged circulation time induced the most marked ABC phenomenon in this research. This study demonstrated that, like PEGylated nanocarriers such as liposomes and polymeric nanoparticles, PEGylated SLNs induced the ABC phenomenon upon repeated injection--the beagle was a valuable experimental animal for this research. Furthermore, the authors considered that a relatively extended circulation time of the initial dose may be the underlying major factor determining the induction of the ABC phenomenon.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Portugal 1 2%
Serbia 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 30%
Student > Master 11 25%
Researcher 5 11%
Student > Doctoral Student 3 7%
Student > Bachelor 3 7%
Other 8 18%
Unknown 1 2%
Readers by discipline Count As %
Medicine and Dentistry 8 18%
Chemistry 8 18%
Pharmacology, Toxicology and Pharmaceutical Science 6 14%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 5 11%
Other 9 20%
Unknown 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2013.
All research outputs
#11,056,832
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#2,164
of 2,456 outputs
Outputs of similar age
#215,370
of 255,782 outputs
Outputs of similar age from International Journal of Nanomedicine
#41
of 66 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,782 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.