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TRPM8 genetic variations associated with COPD risk in the Chinese Han population

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, October 2016
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Title
<em>TRPM8</em>&nbsp;genetic variations associated with COPD risk in the Chinese Han population
Published in
International Journal of Chronic Obstructive Pulmonary Disease, October 2016
DOI 10.2147/copd.s109026
Pubmed ID
Authors

Mingmei Xiong, Jian Wang, Meihua Guo, Qipeng Zhou, Wenju Lu

Abstract

TRPM8 plays a key role in COPD. The development of pulmonary hypertension (PH) in COPD adversely affects survival and exercise capacity. Thus, the aim of this study was to evaluate the possible association between single nucleotide polymorphisms (SNPs) in TRPM8 and COPD or PH in COPD among the Chinese Han population. A total of 513 COPD patients and 506 controls were enrolled in the study. Six tag SNPs (tSNPs) were genotyped. The relationship between COPD or PH in COPD and the six tSNPs was evaluated using the χ(2) test and genetic model analysis. In the rs9789398 polymorphism, the T/C genotype was associated with an increased risk for COPD (P=0.005). Under the assumption of models of inheritance, there was an association between the rs9789398 polymorphism and COPD. In the rs9789675 polymorphism, the G/A genotype was associated with an increased risk for COPD (P=0.021). Furthermore, by the χ(2) test, we found that the minor allele "A" of rs9789675 (odds ratio [OR] =0.63, 95% confidence interval [CI], 0.42-0.97, P=0.034) and the minor allele "C" of rs9789398 (OR =1.59, 95% CI, 1.03-2.44, P=0.034) were associated with a decreased risk of PH in COPD in allele models. In genetic models, the genotypes "GA" and "AA" of rs9789675 were associated with a decreased risk of PH in COPD. The genotypes "TC" and "CC" of rs9789398 were associated with a decreased risk of PH in COPD. Moreover, "CG" of rs1004478 was significantly associated with a decreased risk of PH in COPD. There was a significant association between the five SNPs (rs2362290, rs9789675, rs9789398, rs1003540, and rs104478) in the TRPM8 gene and the risk of PH in COPD. Our findings indicated that rs9789398 in the TRPM8 gene was significantly associated with the risk of COPD in the Chinese Han population. Moreover, rs9789675, rs9789398, and rs1004478 were significantly associated with the risk of PH in COPD. This study provides a novel insight into COPD and PH in the development of COPD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 21%
Student > Ph. D. Student 3 16%
Student > Postgraduate 2 11%
Researcher 2 11%
Student > Bachelor 1 5%
Other 2 11%
Unknown 5 26%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 21%
Nursing and Health Professions 4 21%
Medicine and Dentistry 2 11%
Social Sciences 1 5%
Neuroscience 1 5%
Other 0 0%
Unknown 7 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2016.
All research outputs
#6,472,486
of 8,529,445 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#851
of 1,095 outputs
Outputs of similar age
#174,987
of 251,227 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#82
of 95 outputs
Altmetric has tracked 8,529,445 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,095 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,227 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.