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Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, March 2013
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
2 tweeters

Citations

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33 Dimensions

Readers on

mendeley
41 Mendeley
Title
Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles
Published in
International Journal of Nanomedicine, March 2013
DOI 10.2147/ijn.s37481
Pubmed ID
Authors

Anamaria Orza, Soriţău, Florea, Pana, Bratu, Pal, Florian, Daniel Casciano, Tomuleasa, Olenic, Biris

Abstract

The low rate of survival for patients diagnosed with glioblastoma may be attributed to the existence of a subpopulation of cancer stem cells. These stem cells have certain properties that enable them to resist chemotherapeutic agents and ionizing radiation. Herein, we show that temozolomide-loaded gold nanostructures are efficient in reducing chemoresistance and destroy 82.7% of cancer stem cells compared with a 42% destruction rate using temozolomide alone. Measurements of in vitro cytotoxicity and apoptosis indicate that combination with gold facilitated the ability of temozolomide, an alkylating drug, to alter the resistance of these cancer stem cells, suggesting a new chemotherapy strategy for patients diagnosed with inoperable recurrent malignant glioma.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Romania 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 32%
Student > Bachelor 8 20%
Researcher 6 15%
Student > Doctoral Student 2 5%
Student > Master 2 5%
Other 6 15%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 22%
Medicine and Dentistry 9 22%
Biochemistry, Genetics and Molecular Biology 4 10%
Neuroscience 3 7%
Chemistry 2 5%
Other 7 17%
Unknown 7 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2013.
All research outputs
#3,593,457
of 5,427,448 outputs
Outputs from International Journal of Nanomedicine
#1,025
of 1,444 outputs
Outputs of similar age
#58,868
of 95,240 outputs
Outputs of similar age from International Journal of Nanomedicine
#18
of 51 outputs
Altmetric has tracked 5,427,448 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,444 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,240 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.