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The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

policy
1 policy source
twitter
7 tweeters
facebook
2 Facebook pages

Citations

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51 Dimensions

Readers on

mendeley
62 Mendeley
Title
The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis
Published in
International Journal of Chronic Obstructive Pulmonary Disease, October 2016
DOI 10.2147/copd.s101382
Pubmed ID
Authors

Min Zhu, Ting Wang, Chengdi Wang, Yulin Ji

Abstract

In recent years, the pleiotropic roles of vitamin D have been highlighted in various diseases. However, the association between serum vitamin D and COPD is not well studied. This updated systematic review and meta-analysis aimed to assess the relationship between vitamin D and the risk, severity, and exacerbation of COPD. A systematic literature search was conducted in PubMed, Medline, EMBASE, Chinese National Knowledge Infrastructure, Wanfang, and Weipu databases. The pooled risk estimates were standardized mean difference (SMD) with 95% confidence interval (CI) for vitamin D levels and odds ratio (OR) with 95% CI for vitamin D deficiency. Meta-regression and subgroup analyses were performed on latitude, body mass index, and assay method. A total of 21 studies, including 4,818 COPD patients and 7,175 controls, were included. Meta-analysis showed that lower serum vitamin D levels were found in COPD patients than in controls (SMD: -0.69, 95% CI: -1.00, -0.38, P<0.001), especially in severe COPD (SMD: -0.87, 95% CI: -1.51, -0.22, P=0.001) and COPD exacerbation (SMD: -0.43, 95% CI: -0.70, -0.15, P=0.002). Vitamin D deficiency was associated with increased risk of COPD (OR: 1.77, 95% CI: 1.18, 2.64, P=0.006) and with COPD severity (OR: 2.83, 95% CI: 2.00, 4.00, P<0.001) but not with COPD exacerbation (OR: 1.17, 95% CI: 0.86, 1.59, P=0.326). Assay methods had significant influence on the heterogeneity of vitamin D deficiency and COPD risk. Serum vitamin D levels were inversely associated with COPD risk, severity, and exacerbation. Vitamin D deficiency is associated with increased risk of COPD and severe COPD but not with COPD exacerbation. It is worth considering assay methods in the heterogeneity sources analysis of association between vitamin D deficiency and COPD.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 15%
Student > Bachelor 9 15%
Researcher 7 11%
Student > Doctoral Student 6 10%
Student > Postgraduate 5 8%
Other 11 18%
Unknown 15 24%
Readers by discipline Count As %
Medicine and Dentistry 28 45%
Nursing and Health Professions 5 8%
Biochemistry, Genetics and Molecular Biology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Agricultural and Biological Sciences 1 2%
Other 4 6%
Unknown 19 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2020.
All research outputs
#3,063,077
of 17,986,329 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#376
of 2,021 outputs
Outputs of similar age
#65,694
of 302,566 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#21
of 98 outputs
Altmetric has tracked 17,986,329 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,021 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,566 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.