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Alpha-synuclein in cutaneous small nerve fibers

Overview of attention for article published in Neuropsychiatric Disease and Treatment, October 2016
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Mentioned by

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2 tweeters
facebook
1 Facebook page

Citations

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6 Dimensions

Readers on

mendeley
13 Mendeley
Title
Alpha-synuclein in cutaneous small nerve fibers
Published in
Neuropsychiatric Disease and Treatment, October 2016
DOI 10.2147/ndt.s117423
Pubmed ID
Authors

Timo Siepmann, Ben Min-Woo Illigens, Kristian Barlinn

Abstract

Despite progression in the development of pharmacological therapy, treatment of alpha synucleinopathies, such as Parkinson's disease (PD) and some atypical parkinsonism syndromes, is still challenging. To date, our knowledge of the mechanisms whereby the pathological form of alpha-synuclein causes structural and functional damage to the nervous system is limited and, consequently, there is a lack of specific diagnostic tools to evaluate pathology in these patients and differentiate PD from other neurodegenerative proteinopathies. Recent studies indicated that alpha-synuclein deposition in cutaneous small nerve fibers assessed by skin biopsies might be a valid disease marker of PD and facilitate early differentiation of PD from atypical parkinsonism syndromes. This observation is relevant since early diagnosis may enable timely treatment and improve quality of life. However, challenges include the necessity of standardizing immunohistochemical analysis techniques and the identification of potential distinct patterns of intraneural alpha-synuclein deposition among synucleinopathies. In this perspective, we explore the scientific and clinical opportunities arising from alpha-synuclein assessment using skin biopsies. These include elucidation of the peripheral nervous system pathology of PD and other synucleinopathies, identification of novel targets to study response to neuroprotective treatment, and improvement of clinical management. Furthermore, we discuss future challenges in exploring the diagnostic value of skin biopsy assessment for alpha-synuclein deposition and implementing the technique in clinical practice.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 23%
Student > Master 3 23%
Student > Bachelor 2 15%
Other 1 8%
Researcher 1 8%
Other 0 0%
Unknown 3 23%
Readers by discipline Count As %
Medicine and Dentistry 6 46%
Neuroscience 2 15%
Environmental Science 1 8%
Unknown 4 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2019.
All research outputs
#8,770,000
of 14,537,474 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,329
of 2,487 outputs
Outputs of similar age
#154,736
of 291,214 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#53
of 92 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,214 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.