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Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages.

Overview of attention for article published in Journal of Inflammation Research, March 2013
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  • Average Attention Score compared to outputs of the same age

Mentioned by

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5 Facebook pages

Citations

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28 Dimensions

Readers on

mendeley
36 Mendeley
Title
Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages.
Published in
Journal of Inflammation Research, March 2013
DOI 10.2147/jir.s40269
Pubmed ID
Authors

Christina Ross, Harrison, Christina L Ross, Benjamin S Harrison

Abstract

In the treatment of bacterial infections, antibiotics have proven to be very effective, but the way in which antibiotics are dosed can create a lag time between the administration of the drug and its absorption at the site of insult. The time it takes an antibiotic to reach therapeutic levels can often be significantly increased if the vascular system is compromized. Bacteria can multiply pending the delivery of the drug, therefore, developing treatments that can inhibit the inflammatory response while waiting for antibiotics to take effect could help prevent medical conditions such as septic shock. The aim of this study was to examine the effect of a pulsed electromagnetic field on the production of inflammatory markers tumor necrosis factor (TNF), transcription factor nuclear factor kappa B (NFkB), and the expression of the A20 (tumor necrosis factor-alpha-induced protein 3), in an inflamed-cell model. Lipopolysaccharide-challenged cells were exposed to a pulsed electromagnetic field at various frequencies in order to determine which, if any, frequency would affect the TNF-NFkB-A20 inflammatory response pathway. Our study revealed that cells continuously exposed to a pulsed electromagnetic field at 5 Hz demonstrated significant changes in the downregulation of TNF-α and NFkB and also showed a trend in the down regulation of A20, as compared with controls. This treatment could be beneficial in modulating the immune response, in the presence of infection.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 2 6%
Brazil 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 19%
Student > Master 6 17%
Professor > Associate Professor 4 11%
Student > Doctoral Student 4 11%
Student > Ph. D. Student 4 11%
Other 8 22%
Unknown 3 8%
Readers by discipline Count As %
Medicine and Dentistry 9 25%
Biochemistry, Genetics and Molecular Biology 7 19%
Agricultural and Biological Sciences 5 14%
Engineering 4 11%
Physics and Astronomy 2 6%
Other 4 11%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2018.
All research outputs
#7,513,725
of 12,459,998 outputs
Outputs from Journal of Inflammation Research
#52
of 109 outputs
Outputs of similar age
#72,879
of 144,058 outputs
Outputs of similar age from Journal of Inflammation Research
#2
of 4 outputs
Altmetric has tracked 12,459,998 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 109 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,058 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.