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Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery

Overview of attention for article published in International Journal of Nanomedicine, October 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

policy
1 policy source
video
1 YouTube creator

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
30 Mendeley
Title
Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery
Published in
International Journal of Nanomedicine, October 2011
DOI 10.2147/ijn.s23962
Pubmed ID
Authors

Jurja C Coyuco, Yuanjie Liu, Bee-Jen Tan, Gigi NC Chiu

Abstract

Although carbon nanomaterials (CNMs) have been increasingly studied for their biomedical applications, there is limited research on these novel materials for oral drug delivery. As such, this study aimed to explore the potential of CNMs in oral drug delivery, and the objectives were to evaluate CNM cytotoxicity and their abilities to modulate paracellular transport and the P-glycoprotein (P-gp) efflux pump. Three types of functionalized CNMs were studied, including polyhydroxy small-gap fullerenes (OH-fullerenes), carboxylic acid functionalized single-walled carbon nanotubes (f SWCNT-COOH) and poly(ethylene glycol) functionalized single-walled carbon nanotubes (f SWCNT-PEG), using the well-established Caco-2 cell monolayer to represent the intestinal epithelium. All three CNMs had minimum cytotoxicity on Caco-2 cells, as demonstrated through lactose dehydrogenase release and 3-(4,5-dimethyliazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Of the three CNMs, f SWCNT-COOH significantly reduced transepithelial electrical resistance and enhanced transport of Lucifer Yellow across the Caco-2 monolayer. Confocal fluorescence microscopy showed that f SWCNT-COOH treated cells had the highest perturbation in the distribution of ZO-1, a protein marker of tight junction, suggesting that f SWCNT-COOH could enhance paracellular permeability via disruption of tight junctions. This modulating effect of f SWCNT-COOH can be reversed over time. Furthermore, cellular accumulation of the P-gp substrate, rhodamine-123, was significantly increased in cells treated with f SWCNT-COOH, suggestive of P-gp inhibition. Of note, f SWCNT-PEG could increase rhodamine-123 accumulation without modifying the tight junction. Collectively, these results suggest that the functionalized CNMs could be useful as modulators for oral drug delivery, and the differential effects on the intestinal epithelium imparted by different types of CNMs would create unique opportunities for drug-specific oral delivery applications.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 3%
Poland 1 3%
Germany 1 3%
Unknown 27 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 27%
Student > Ph. D. Student 5 17%
Student > Bachelor 3 10%
Student > Master 3 10%
Student > Doctoral Student 2 7%
Other 4 13%
Unknown 5 17%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 20%
Agricultural and Biological Sciences 6 20%
Medicine and Dentistry 4 13%
Chemistry 4 13%
Biochemistry, Genetics and Molecular Biology 2 7%
Other 1 3%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2020.
All research outputs
#8,262,107
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#1,007
of 4,123 outputs
Outputs of similar age
#48,174
of 143,951 outputs
Outputs of similar age from International Journal of Nanomedicine
#20
of 54 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.