↓ Skip to main content

Dove Medical Press

Article Metrics

Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery

Overview of attention for article published in International Journal of Nanomedicine, October 2011
Altmetric Badge

Mentioned by

video
1 video uploader

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
21 Mendeley
Title
Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery
Published in
International Journal of Nanomedicine, October 2011
DOI 10.2147/ijn.s23962
Pubmed ID
Authors

Gigi Chiu, Coyuco, Liu, Tan

Abstract

Although carbon nanomaterials (CNMs) have been increasingly studied for their biomedical applications, there is limited research on these novel materials for oral drug delivery. As such, this study aimed to explore the potential of CNMs in oral drug delivery, and the objectives were to evaluate CNM cytotoxicity and their abilities to modulate paracellular transport and the P-glycoprotein (P-gp) efflux pump. Three types of functionalized CNMs were studied, including polyhydroxy small-gap fullerenes (OH-fullerenes), carboxylic acid functionalized single-walled carbon nanotubes (f SWCNT-COOH) and poly(ethylene glycol) functionalized single-walled carbon nanotubes (f SWCNT-PEG), using the well-established Caco-2 cell monolayer to represent the intestinal epithelium. All three CNMs had minimum cytotoxicity on Caco-2 cells, as demonstrated through lactose dehydrogenase release and 3-(4,5-dimethyliazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Of the three CNMs, f SWCNT-COOH significantly reduced transepithelial electrical resistance and enhanced transport of Lucifer Yellow across the Caco-2 monolayer. Confocal fluorescence microscopy showed that f SWCNT-COOH treated cells had the highest perturbation in the distribution of ZO-1, a protein marker of tight junction, suggesting that f SWCNT-COOH could enhance paracellular permeability via disruption of tight junctions. This modulating effect of f SWCNT-COOH can be reversed over time. Furthermore, cellular accumulation of the P-gp substrate, rhodamine-123, was significantly increased in cells treated with f SWCNT-COOH, suggestive of P-gp inhibition. Of note, f SWCNT-PEG could increase rhodamine-123 accumulation without modifying the tight junction. Collectively, these results suggest that the functionalized CNMs could be useful as modulators for oral drug delivery, and the differential effects on the intestinal epithelium imparted by different types of CNMs would create unique opportunities for drug-specific oral delivery applications.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 5%
Poland 1 5%
China 1 5%
United States 1 5%
Unknown 17 81%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 33%
Student > Ph. D. Student 5 24%
Student > Master 2 10%
Student > Doctoral Student 2 10%
Student > Bachelor 1 5%
Other 4 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 33%
Chemistry 4 19%
Pharmacology, Toxicology and Pharmaceutical Science 3 14%
Medicine and Dentistry 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Other 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2011.
All research outputs
#11,056,804
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#2,140
of 2,456 outputs
Outputs of similar age
#120,782
of 144,509 outputs
Outputs of similar age from International Journal of Nanomedicine
#32
of 51 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,509 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.