| Title |
Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
|
|---|---|
| Published in |
International Journal of Nanomedicine, May 2011
|
| DOI | 10.2147/ijn.s18755 |
| Pubmed ID | |
| Authors |
Yupeng Chen, Shang Song, Zhimin Yan, Hicham Fenniri, Thomas J Webster |
| Abstract |
Rosette nanotubes (RNTs) are novel, self-assembled, biomimetic, synthetic drug delivery materials suitable for numerous medical applications. Because of their amphiphilic character and hollow architecture, RNTs can be used to encapsulate and deliver hydrophobic drugs otherwise difficult to deliver in biological systems. Another advantage of using RNTs for drug delivery is their biocompatibility, low cytotoxicity, and their ability to engender a favorable, biologically-inspired environment for cell adhesion and growth. In this study, a method to incorporate dexamethasone (DEX, an inflammatory and a bone growth promoting steroid) into RNTs was developed. The drug-loaded RNTs were characterized using diffusion ordered nuclear magnetic resonance spectroscopy (DOSY NMR) and UV-Vis spectroscopy. Results showed for the first time that DEX can be easily and quickly encapsulated into RNTs and released to promote osteoblast (bone-forming cell) functions over long periods of time. As a result, RNTs are presented as a novel material for the targeted delivery of hydrophobic drugs otherwise difficult to deliver. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 10% |
| Student > Ph. D. Student | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Professor > Associate Professor | 1 | 3% |
| Unknown | 22 | 76% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Materials Science | 1 | 3% |
| Engineering | 1 | 3% |
| Unknown | 23 | 79% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2020.
All research outputs
#8,261,756
of 25,371,288 outputs
Outputs from International Journal of Nanomedicine
#1,007
of 4,123 outputs
Outputs of similar age
#44,014
of 121,547 outputs
Outputs of similar age from International Journal of Nanomedicine
#13
of 33 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,547 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.