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Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone

Overview of attention for article published in International Journal of Nanomedicine, May 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

patent
45 patents
video
1 video uploader

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
29 Mendeley
Title
Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
Published in
International Journal of Nanomedicine, May 2011
DOI 10.2147/ijn.s18755
Pubmed ID
Authors

Thomas J Webster, Chen, Shang Song, Zhimin Yan, Hicham Fenirri

Abstract

Rosette nanotubes (RNTs) are novel, self-assembled, biomimetic, synthetic drug delivery materials suitable for numerous medical applications. Because of their amphiphilic character and hollow architecture, RNTs can be used to encapsulate and deliver hydrophobic drugs otherwise difficult to deliver in biological systems. Another advantage of using RNTs for drug delivery is their biocompatibility, low cytotoxicity, and their ability to engender a favorable, biologically-inspired environment for cell adhesion and growth. In this study, a method to incorporate dexamethasone (DEX, an inflammatory and a bone growth promoting steroid) into RNTs was developed. The drug-loaded RNTs were characterized using diffusion ordered nuclear magnetic resonance spectroscopy (DOSY NMR) and UV-Vis spectroscopy. Results showed for the first time that DEX can be easily and quickly encapsulated into RNTs and released to promote osteoblast (bone-forming cell) functions over long periods of time. As a result, RNTs are presented as a novel material for the targeted delivery of hydrophobic drugs otherwise difficult to deliver.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 1 3%
Unknown 28 97%
Readers by discipline Count As %
Unspecified 1 3%
Unknown 28 97%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#3,540,110
of 12,585,503 outputs
Outputs from International Journal of Nanomedicine
#359
of 2,474 outputs
Outputs of similar age
#40,794
of 145,714 outputs
Outputs of similar age from International Journal of Nanomedicine
#11
of 51 outputs
Altmetric has tracked 12,585,503 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,474 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 145,714 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.