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Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease

Overview of attention for article published in Neuropsychiatric Disease and Treatment, November 2016
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22 Mendeley
Title
Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease
Published in
Neuropsychiatric Disease and Treatment, November 2016
DOI 10.2147/ndt.s115505
Pubmed ID
Authors

Soham Rej, Mahwesh Saleem, Nathan Herrmann, Anthi Stefatos, Allison Rau, Krista L Lanctôt

Abstract

Statins have been associated with decreased cognition due to the effects of low concentrations of low-density lipoprotein (LDL) on brain function. This has remained controversial and is particularly relevant to patients with coronary artery disease (CAD), who have an increased risk of cognitive decline and are frequently prescribed statins. This study hypothesized that low concentration of LDL is associated with poor cognition in CAD patients using statins. It also explored the association between high-dose versus low-dose statins on cognition in this population. Baseline cross-sectional data from a longitudinal study of 120 statin-using CAD patients were examined (mean statin duration 25±43 months). The main outcomes were measures of global cognition and cognitive domains, with poor cognition defined as cognitive performance ≤1 standard deviation below the population age and education adjusted means. A battery of cognitive tests was used to assess verbal memory, executive function, speed of processing, visuospatial memory, and global cognition. Adjusting for age, sex, education, and other covariates, multivariable logistic regression analyses assessed associations between low LDL levels (<1.5 mmol/L), statin use, and poor cognition. LDL levels were not associated with global cognition or individual cognitive domains. High-dose statin use was associated with higher visuospatial memory (odds ratio, OR [95% confidence interval, CI] =0.12 [0.02-0.66], P=0.01) and executive functioning (OR =0.25 [0.06-0.99], P=0.05). This effect was independent of covariates such as LDL levels. Low LDL levels do not appear to be associated with poor cognition in CAD patients using statins. Whether high-dose statin use may have positive effects on cognition in CAD patients could be investigated in future studies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Egypt 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 27%
Student > Ph. D. Student 4 18%
Student > Bachelor 2 9%
Professor 1 5%
Researcher 1 5%
Other 1 5%
Unknown 7 32%
Readers by discipline Count As %
Psychology 4 18%
Medicine and Dentistry 4 18%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Sports and Recreations 1 5%
Nursing and Health Professions 1 5%
Other 2 9%
Unknown 8 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2016.
All research outputs
#11,040,010
of 14,537,474 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,681
of 2,487 outputs
Outputs of similar age
#189,549
of 286,174 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#63
of 82 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,174 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.