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Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation

Overview of attention for article published in OncoTargets and therapy, March 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

twitter
1 tweeter
patent
3 patents

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
30 Mendeley
Title
Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation
Published in
OncoTargets and therapy, March 2013
DOI 10.2147/ott.s40992
Pubmed ID
Authors

Xuan Zhang, Duan, Zhao, Ren, Wang, Yu, Li, Qiang Zhang

Abstract

Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood-brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood-brain barrier, as well as having potential antitumor activity on brain tumors, the purpose of this study is to investigate the antitumor activity of DCA on C6 glioma cells in vitro and in vivo. DCA inhibited C6 glioma cell proliferation, induced C6 cell apoptosis, and arrested C6 cells in S phase. DCA can inhibit the expression of heat shock proteins 70 (Hsp70) in a dose-dependent and time-dependent manner (P < 0.01). Our in vivo antitumor effect results indicated that DCA markedly inhibited the growth of C6 glioma tumors in both C6 brain tumor-bearing rats and C6 tumor-bearing nude mice (P < 0.01). DCA significantly induced the ROS production and decreased the mitochondrial membrane potential in tumor tissues. Our in vivo antitumor effect results also indicated that DCA has potential antiangiogenic effects. In conclusion, DCA may be a viable therapeutic agent in the treatment of gliomas.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 30%
Student > Doctoral Student 3 10%
Researcher 3 10%
Student > Bachelor 2 7%
Other 2 7%
Other 8 27%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Medicine and Dentistry 7 23%
Biochemistry, Genetics and Molecular Biology 5 17%
Physics and Astronomy 1 3%
Computer Science 1 3%
Other 4 13%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2020.
All research outputs
#5,019,555
of 16,810,341 outputs
Outputs from OncoTargets and therapy
#195
of 2,421 outputs
Outputs of similar age
#45,482
of 159,002 outputs
Outputs of similar age from OncoTargets and therapy
#7
of 29 outputs
Altmetric has tracked 16,810,341 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,421 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.