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Superior antidepressant effect occurring 1 month after rTMS: add-on rTMS for subjects with medication-resistant depression

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2013
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Title
Superior antidepressant effect occurring 1 month after rTMS: add-on rTMS for subjects with medication-resistant depression
Published in
Neuropsychiatric Disease and Treatment, March 2013
DOI 10.2147/ndt.s40466
Pubmed ID
Authors

Shao-Tsu Chen, Chen Shaw-Ji, Chang Chun-Hung, Tsai Hsin-Chi, Chaucer C. H. Lin

Abstract

Depression is a major psychiatric disorder. The standard treatment for depression is antidepressant medication, but the responses to antidepressant treatment are only partial, even poor, among 30%-45% of patients. Refractory depression is defined as depression that does not respond to antidepressant therapy after 4 weeks of use. There is evidence that repetitive transcranial magnetic stimulation (rTMS) may exert effects in treating psychiatric disorder through moderating focal neuronal functions. High-frequency rTMS on the left prefrontal area and low-frequency rTMS on the right prefrontal area were shown to be effective in alleviating depressive symptoms. Given the statistically significant antidepressant effectiveness noted, the clinical application of rTMS as a depression treatment warrants further studies. Application of rTMS as an add-on therapy would be a practical research model. High-frequency (5-20 Hz) rTMS over the left dorsolateral prefrontal cortex was found to have a significant effect on medication-resistant depression. In the present study, we not only measured the acute antidepressant effect of rTMS during treatment and immediately after its completion but also evaluated participants 1 month after completion of the treatment protocol. Study participants were divided into two groups: an active rTMS group (n = 10) and a sham group (n = 10). The active rTMS group was defined as participants who received the rTMS protocol, and the sham group was defined as participants who received a sham rTMS procedure. A significant Hamilton Depression Rating Scale score reduction was observed in both groups after the fifth and tenth treatments. However, those in the active rTMS group maintained their improvement as measured one month after completion of the rTMS protocol. Participants who received active rTMS were more likely to have persistent improvement in depression scores than participants who received sham rTMS.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Germany 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 30%
Student > Master 6 14%
Other 5 11%
Student > Postgraduate 4 9%
Researcher 4 9%
Other 6 14%
Unknown 6 14%
Readers by discipline Count As %
Medicine and Dentistry 13 30%
Neuroscience 6 14%
Psychology 4 9%
Agricultural and Biological Sciences 4 9%
Unspecified 2 5%
Other 6 14%
Unknown 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2013.
All research outputs
#2,901,181
of 3,629,407 outputs
Outputs from Neuropsychiatric Disease and Treatment
#572
of 677 outputs
Outputs of similar age
#66,088
of 85,496 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#36
of 52 outputs
Altmetric has tracked 3,629,407 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 677 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,496 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.