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Does calcium channel blockade have a role in prevention of expression of sepsis in renal transplant recipients?

Overview of attention for article published in International Journal of Nephrology and Renovascular Disease, November 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#8 of 129)
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
8 tweeters

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
18 Mendeley
Title
Does calcium channel blockade have a role in prevention of expression of sepsis in renal transplant recipients?
Published in
International Journal of Nephrology and Renovascular Disease, November 2016
DOI 10.2147/ijnrd.s121492
Pubmed ID
Authors

John A D'Elia, Ray E Gleason, Anthony P Monaco, Larry A Weinrauch

Abstract

Many antihypertensive agents have been demonstrated to assist in preservation of kidney function, among them those that modulate calcium channels. Calcium channel blockers may also be of value in protecting hemodialysis patients from complications of sepsis. In diabetic recipients of kidney transplant allografts treated with cyclosporine, calcium channel blockade has been retrospectively linked to improved graft preservation and to fewer episodes of sepsis. This brief review outlines clinical and experimental publications on potential protection from sepsis by addition of calcium channel blockers to standard antibiotic therapy in individuals who may or may not have normal kidney function, or in the presence or absence of immunosuppression. Such mechanisms include blockade of antibiotic cytosolic extrusion in the cases of Pneumococci, Mycobacterium tuberculosis, Plasmodium falciparum malaria, or Schistosoma mansoni; blockade of the calcineurin/calmodulin pathway (in immunosuppressed patients allowing for lower dosage of cyclosporine); stabilization of calcium movement at the level of sarcoplasmic reticulum by which shock (vasopressor instability) is prevented; or of cytosolic calcium influx and cell death (in the case of allograft acute tubular necrosis). Given the high cost of development of new antibiotics, a role for generic calcium channel blockade in sepsis prevention should be pursued by additional studies to investigate potential links between blockade of calcium channels and expression of sepsis in at-risk populations.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 17%
Student > Bachelor 3 17%
Other 2 11%
Student > Master 2 11%
Student > Ph. D. Student 1 6%
Other 4 22%
Unknown 3 17%
Readers by discipline Count As %
Medicine and Dentistry 9 50%
Agricultural and Biological Sciences 1 6%
Nursing and Health Professions 1 6%
Social Sciences 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 1 6%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2017.
All research outputs
#2,491,598
of 11,414,199 outputs
Outputs from International Journal of Nephrology and Renovascular Disease
#8
of 129 outputs
Outputs of similar age
#80,801
of 319,167 outputs
Outputs of similar age from International Journal of Nephrology and Renovascular Disease
#1
of 10 outputs
Altmetric has tracked 11,414,199 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 129 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,167 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them