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Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management

Overview of attention for article published in OncoTargets and therapy, March 2013
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Mentioned by

twitter
1 tweeter

Citations

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45 Dimensions

Readers on

mendeley
66 Mendeley
citeulike
1 CiteULike
Title
Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management
Published in
OncoTargets and therapy, March 2013
DOI 10.2147/ott.s34680
Pubmed ID
Authors

Timothy Chan, Ho, Turcan

Abstract

The emergence of epigenetic mechanisms as key regulators of gene expression has led to dramatic advances in understanding cancer biology. Driven by complex layers that include aberrant DNA methylation and histone modification, epigenetic aberrations have emerged as critical processes that disrupt cellular machinery and homeostasis. Recent discoveries have already translated into successful clinical trials and improved patient care, with several agents approved for hematologic disease and others undergoing study. As the field matures, substantial challenges persist that will require resolution. These include the need to decipher more fully the interplay between the epigenetic and genetic machinery, patient selection and improving treatment efficacy in solid tumors, and optimizing combination therapies to counteract chemoresistance and minimize adverse effects. Here, we review recent progress in epigenetic treatments and consider their implications for future cancer therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Portugal 1 2%
Brazil 1 2%
Czechia 1 2%
Spain 1 2%
Unknown 60 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 23%
Researcher 12 18%
Student > Ph. D. Student 10 15%
Student > Doctoral Student 6 9%
Student > Bachelor 5 8%
Other 17 26%
Unknown 1 2%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 33%
Medicine and Dentistry 19 29%
Biochemistry, Genetics and Molecular Biology 17 26%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Psychology 1 2%
Other 3 5%
Unknown 3 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2013.
All research outputs
#18,336,865
of 22,707,247 outputs
Outputs from OncoTargets and therapy
#1,483
of 2,927 outputs
Outputs of similar age
#147,553
of 194,013 outputs
Outputs of similar age from OncoTargets and therapy
#24
of 31 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,927 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,013 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.