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Triple-negative (ER, PgR, HER-2/neu) breast cancer in Indian women

Overview of attention for article published in Breast cancer targets and therapy, March 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
20 Mendeley
Title
Triple-negative (ER, PgR, HER-2/neu) breast cancer in Indian women
Published in
Breast cancer targets and therapy, March 2011
DOI 10.2147/bctt.s17094
Pubmed ID
Authors

Rajeev Singhai, Rajeev Singhai, A. W. Patil

Abstract

The aim of our study was to analyze triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PgR), and the human epidermal growth factor receptor 2 (HER-2/neu) and which represents a subset of breast cancer with different biologic behavior. We investigated the clinicopathological characteristics and prognostic indicators of lymph node-negative TN breast cancer. Medical records were reviewed from patients with node-negative breast cancer who underwent curative surgery at Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, from May 2007 to October 2010. Clinicopathological variables and clinical outcomes were evaluated. Among 683 patients included, 136 had TN breast cancer and 529 had non-TN breast cancer. TN breast cancer correlated with younger age (<35 years, P = 0.003) and a higher histopathologic and nuclear grade (P < 0.001). It also correlated with a molecular profile associated with biological aggressiveness: negative for Bcl-2 expression (P < 0.001), positive for the epidermal growth factor receptor (P = 0.003), and a high level of p53 (P < 0.001) and Ki-67 expression (P < 0.00). The relapse rates during the follow-up period (median 56.8 months) were 14.7% for TN breast cancer and 6.6% for non-TN breast cancer (P = 0.004). Relapse-free survival (RFS) was significantly shorter among patients with TN breast cancer compared with those with non-TN breast cancer: 3.5-year RFS rate 85.5% versus 94.2%, respectively; P = 0.001. On multivariate analysis, young age, close resection margin, and triple negativity were independent predictors of shorter RFS. TN breast cancer had a higher relapse rate and more aggressive clinicopathological characteristics than non-TN in node-negative breast cancer. Thus, TN breast cancer should be integrated into risk factor analysis for node-negative breast cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 25%
Unspecified 3 15%
Student > Ph. D. Student 3 15%
Student > Master 3 15%
Student > Bachelor 2 10%
Other 4 20%
Readers by discipline Count As %
Medicine and Dentistry 11 55%
Agricultural and Biological Sciences 5 25%
Unspecified 3 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2012.
All research outputs
#328,624
of 3,628,883 outputs
Outputs from Breast cancer targets and therapy
#3
of 43 outputs
Outputs of similar age
#10,575
of 84,855 outputs
Outputs of similar age from Breast cancer targets and therapy
#1
of 5 outputs
Altmetric has tracked 3,628,883 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 43 research outputs from this source. They receive a mean Attention Score of 3.3. This one scored the same or higher as 40 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,855 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them