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Evaluation of β-cyclodextrin-modified gemini surfactant-based delivery systems in melanoma models

Overview of attention for article published in International Journal of Nanomedicine, December 2016
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

twitter
1 tweeter
facebook
1 Facebook page

Citations

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8 Dimensions

Readers on

mendeley
10 Mendeley
Title
Evaluation of β-cyclodextrin-modified gemini surfactant-based delivery systems in melanoma models
Published in
International Journal of Nanomedicine, December 2016
DOI 10.2147/ijn.s121156
Pubmed ID
Authors

Deborah Michel, Waleed Mohammed-Saeid, Heather Getson, Caitlin Roy, Masoomeh Poorghorban, Jackson M. Chitanda, Ronald Verrall, Ildiko Badea

Abstract

Novel drug delivery systems are developed to improve the biological behavior of poorly soluble drugs and to improve therapeutic outcomes. In melanoma therapy, the goal is efficient drug delivery and mitigation of drug resistance. Melphalan (Mel), a currently used therapeutic agent for melanoma, requires solvent system for solubilization, leading to poor chemical stability. Moreover, drug resistance often renders the drug inefficient in clinical setting. A novel β-cyclodextrin-modified gemini surfactant (CDgemini) delivery system was developed to incorporate Mel in order to improve its physicochemical and biological behavior. Melphalan nanoparticles (Mel-NP) showed optimal particle size in the 200-250 nm range for endocytosis and induced significantly higher cell death compared with Mel (50% of inhibitory concentration [IC50] of 36 µM for the complexes vs 82 µM for Mel). The CDgemini delivery system did not alter the pathway of the cellular death triggered by Mel and caused no intrinsic toxicity to the cells. The Mel-NP complexes induced significant cell death in melanoma cells that were rendered resistant to Mel. These findings demonstrate in principle the applicability of the CDgemini delivery system as safe and efficient alternative to the current melanoma therapy, especially in chemoresistant cases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 20%
Student > Ph. D. Student 1 10%
Student > Postgraduate 1 10%
Unknown 6 60%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 20%
Agricultural and Biological Sciences 2 20%
Medicine and Dentistry 1 10%
Unknown 5 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2016.
All research outputs
#4,481,225
of 8,769,477 outputs
Outputs from International Journal of Nanomedicine
#730
of 1,925 outputs
Outputs of similar age
#152,389
of 300,094 outputs
Outputs of similar age from International Journal of Nanomedicine
#24
of 83 outputs
Altmetric has tracked 8,769,477 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,925 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.