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Current and future role of biomarkers in Crohn's disease risk assessment and treatment

Overview of attention for article published in Clinical and Experimental Gastroenterology, July 2011
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Citations

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61 Mendeley
Title
Current and future role of biomarkers in Crohn's disease risk assessment and treatment
Published in
Clinical and Experimental Gastroenterology, July 2011
DOI 10.2147/ceg.s18187
Pubmed ID
Authors

Tamboli, Doman, Patel

Abstract

Crohn's disease (CD), a chronic inflammatory bowel disease (IBD), occurs in genetically susceptible individuals who develop aberrant immune responses to endoluminal bacteria. Recurrent inflammation increases the risk of several complications. Despite use of a traditional "step-up" therapy with corticosteroids and immunomodulators, most CD patients eventually require surgery at some time in their disease course. Newer biologic agents have been remarkably effective in controlling severe disease. Thus, "top-down," early aggressive therapy has been proposed to yield better outcomes, especially in complicated disease. However, safety and cost issues mandate the need for careful patient selection. Identification of high-risk candidates who may benefit from aggressive therapy is becoming increasingly relevant. Serologic and genetic markers of CD have great potential in this regard. The aim of this review is to highlight the clinical relevance of these markers for diagnostics and prognostication.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Portugal 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 28%
Other 9 15%
Student > Ph. D. Student 8 13%
Student > Master 6 10%
Student > Postgraduate 4 7%
Other 13 21%
Unknown 4 7%
Readers by discipline Count As %
Medicine and Dentistry 28 46%
Agricultural and Biological Sciences 12 20%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Biochemistry, Genetics and Molecular Biology 3 5%
Economics, Econometrics and Finance 2 3%
Other 5 8%
Unknown 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2011.
All research outputs
#20,194,150
of 22,711,242 outputs
Outputs from Clinical and Experimental Gastroenterology
#253
of 306 outputs
Outputs of similar age
#108,213
of 117,142 outputs
Outputs of similar age from Clinical and Experimental Gastroenterology
#3
of 3 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 306 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,142 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.