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Bronchodilator response of advanced lung function parameters depending on COPD severity

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, November 2016
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Mentioned by

twitter
2 tweeters

Citations

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1 Dimensions

Readers on

mendeley
12 Mendeley
Title
Bronchodilator response of advanced lung function parameters depending on COPD severity
Published in
International Journal of Chronic Obstructive Pulmonary Disease, November 2016
DOI 10.2147/copd.s111573
Pubmed ID
Authors

Linnea Jarenbäck, Göran Eriksson, Stefan Peterson, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson

Abstract

COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD patients and controls. Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium. Most pulmonary function parameters showed a linear increase in response to decreased FEV1%p. The subjects were divided into groups of FEV1%p <65 and >65, and the findings from continuous analysis were verified. The exceptions to this linear response were inspiratory capacity (IC), forced vital capacity (FVC), FEV1/FVC and expiratory resistance (Rex), which showed a segmented response relationship to FEV1%p. IC and FVC, with break points (BP) of 57 and 58 FEV1%p respectively, showed no response above, but an incresed slope below the BP. In addition, in patients with FEV1%p <65 and >65, response of FEV1%p did not correlate to response of volume parameters. Response of several advanced lung function parameters differs depending on patients' baseline FEV1%p, and specifically response of volume parameters is most pronounced in COPD patients with FEV1%p <65. Volume and resistance responses do not follow the flow response measured with FEV1 and may thus be used as a complement to FEV1 reversibility to identify flow, volume and resistance responders.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 25%
Researcher 3 25%
Professor 2 17%
Student > Ph. D. Student 1 8%
Student > Bachelor 1 8%
Other 2 17%
Readers by discipline Count As %
Medicine and Dentistry 5 42%
Unspecified 2 17%
Nursing and Health Professions 2 17%
Physics and Astronomy 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2017.
All research outputs
#6,932,407
of 11,590,856 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#781
of 1,355 outputs
Outputs of similar age
#164,048
of 321,239 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#51
of 91 outputs
Altmetric has tracked 11,590,856 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,355 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,239 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.