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Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Overview of attention for article published in International Journal of Nanomedicine, April 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

twitter
2 tweeters
patent
2 patents
facebook
6 Facebook pages

Citations

dimensions_citation
77 Dimensions

Readers on

mendeley
112 Mendeley
Title
Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
Published in
International Journal of Nanomedicine, April 2012
DOI 10.2147/ijn.s30085
Pubmed ID
Authors

Nianping Feng

Abstract

The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of -16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Serbia 1 <1%
Unknown 111 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 23%
Student > Master 22 20%
Student > Doctoral Student 15 13%
Researcher 9 8%
Other 7 6%
Other 18 16%
Unknown 15 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 29 26%
Agricultural and Biological Sciences 18 16%
Medicine and Dentistry 13 12%
Chemistry 11 10%
Biochemistry, Genetics and Molecular Biology 6 5%
Other 9 8%
Unknown 26 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2020.
All research outputs
#2,768,132
of 17,648,139 outputs
Outputs from International Journal of Nanomedicine
#149
of 3,210 outputs
Outputs of similar age
#25,667
of 164,815 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 63 outputs
Altmetric has tracked 17,648,139 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,210 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,815 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.