Title |
Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21Cip1 pathway and restores osteoblastic differentiation in human dental pulp stem cells
|
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Published in |
International Journal of Nanomedicine, September 2012
|
DOI | 10.2147/ijn.s31723 |
Pubmed ID | |
Authors |
Yoon Jung Choi, Jue Yeon Lee, Chong Pyoung Chung, Yoon Jeong Park |
Abstract |
Human dental pulp stem cells (DPSCs) have potential applications in tissue regeneration because of their convenient cell harvesting procedures and multipotent capacity. However, the tissue regenerative potential of DPSCs is known to be negatively regulated by aging in long-term culture and under oxidative stress. With an aim of reducing cellular senescence and oxidative stress in DPSCs, an intracellular delivery system for superoxide dismutase 1 (SOD1) was developed. We conjugated SOD1 with a cell-penetrating peptide known as low-molecular weight protamine (LMWP), and investigated the effect of LMWP-SOD1 conjugates on hydrogen peroxide-induced cellular senescence and osteoblastic differentiation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 20% |
Student > Ph. D. Student | 7 | 17% |
Student > Bachelor | 7 | 17% |
Student > Doctoral Student | 5 | 12% |
Lecturer > Senior Lecturer | 3 | 7% |
Other | 9 | 22% |
Unknown | 2 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 27% |
Medicine and Dentistry | 10 | 24% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Chemistry | 3 | 7% |
Other | 6 | 15% |
Unknown | 4 | 10% |