| Title |
Intravenous magnetic nanoparticle cancer hyperthermia
|
|---|---|
| Published in |
International Journal of Nanomedicine, July 2013
|
| DOI | 10.2147/ijn.s43770 |
| Pubmed ID | |
| Authors |
Hui S Huang, James F Hainfeld |
| Abstract |
Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 304 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Brazil | 2 | <1% |
| Japan | 2 | <1% |
| India | 2 | <1% |
| Canada | 2 | <1% |
| Spain | 2 | <1% |
| Singapore | 1 | <1% |
| Australia | 1 | <1% |
| Taiwan | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 286 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 84 | 28% |
| Student > Master | 49 | 16% |
| Researcher | 39 | 13% |
| Student > Bachelor | 36 | 12% |
| Student > Doctoral Student | 12 | 4% |
| Other | 44 | 14% |
| Unknown | 40 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 44 | 14% |
| Engineering | 43 | 14% |
| Agricultural and Biological Sciences | 37 | 12% |
| Physics and Astronomy | 36 | 12% |
| Materials Science | 24 | 8% |
| Other | 66 | 22% |
| Unknown | 54 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2021.
All research outputs
#3,105,034
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#158
of 4,123 outputs
Outputs of similar age
#25,615
of 206,704 outputs
Outputs of similar age from International Journal of Nanomedicine
#2
of 88 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,704 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.