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Brain-derived neurotrophic factor: role in depression and suicide

Overview of attention for article published in Neuropsychiatric Disease and Treatment, August 2009
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
twitter
9 tweeters
wikipedia
2 Wikipedia pages
video
2 video uploaders

Citations

dimensions_citation
217 Dimensions

Readers on

mendeley
298 Mendeley
citeulike
2 CiteULike
Title
Brain-derived neurotrophic factor: role in depression and suicide
Published in
Neuropsychiatric Disease and Treatment, August 2009
DOI 10.2147/ndt.s5700
Pubmed ID
Authors

Yogesh Dwivedi

Abstract

Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons and in synaptic plasticity. Several lines of evidence suggest that BDNF is involved in depression, such that the expression of BDNF is decreased in depressed patients. In addition, antidepressants up-regulate the expression of BDNF. This has led to the proposal of the "neurotrophin hypothesis of depression". Increasing evidence demonstrates that suicidal behavior is also associated with lower expression of BDNF, which may be independent from depression. Recent genetic studies also support a link of BDNF to depression/suicidal behavior. Not only BDNF, but abnormalities in its cognate receptor tropomycin receptor kinase B (TrkB) and its splice variant (TrkB.T1) have also been reported in depressed/suicidal patients. It has been suggested that epigenetic modulation of the Bdnf and Trkb genes may contribute to their altered expression and functioning. More recently, impairment in the functioning of pan75 neurotrophin receptor has been reported in suicide brain specimens. pan75 neurotrophin receptor is a low-affinity neurotrophin receptor that, when expressed in conjunction with low availability of neurotropins/Trks, induces apoptosis. Overall, these studies suggest the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. This review focuses on the critical evidence demonstrating the involvement of BDNF in depression and suicide.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 298 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Australia 1 <1%
Italy 1 <1%
Switzerland 1 <1%
Brazil 1 <1%
Canada 1 <1%
Portugal 1 <1%
Unknown 289 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 57 19%
Student > Bachelor 55 18%
Student > Ph. D. Student 52 17%
Researcher 29 10%
Student > Doctoral Student 20 7%
Other 51 17%
Unknown 34 11%
Readers by discipline Count As %
Medicine and Dentistry 61 20%
Neuroscience 49 16%
Agricultural and Biological Sciences 45 15%
Psychology 28 9%
Biochemistry, Genetics and Molecular Biology 27 9%
Other 43 14%
Unknown 45 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2021.
All research outputs
#578,307
of 19,148,527 outputs
Outputs from Neuropsychiatric Disease and Treatment
#64
of 2,766 outputs
Outputs of similar age
#4,269
of 129,809 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#2
of 47 outputs
Altmetric has tracked 19,148,527 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,766 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 129,809 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.