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Abnormal whole-brain functional connectivity in patients with primary insomnia

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2017
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Citations

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18 Mendeley
Title
Abnormal whole-brain functional connectivity in patients with primary insomnia
Published in
Neuropsychiatric Disease and Treatment, February 2017
DOI 10.2147/ndt.s128811
Pubmed ID
Authors

Chao Li, Mengshi Dong, Yi Yin, Kelei Hua, Shishun Fu, Guihua Jiang

Abstract

The investigation of the mechanism of insomnia could provide the basis for improved understanding and treatment of insomnia. The aim of this study is to investigate the abnormal functional connectivity throughout the entire brain of insomnia patients, and analyze the global distribution of these abnormalities. Whole brains of 50 patients with insomnia and 40 healthy controls were divided into 116 regions and abnormal connectivities were identified by comparing the Pearson's correlation coefficients of each pair using general linear model analyses with covariates of age, sex, and duration of education. In patients with insomnia, regions that relate to wakefulness, emotion, worry/rumination, saliency/attention, and sensory-motor showed increased positive connectivity with each other; however, regions that often restrain each other, such as regions in salience network with regions in default mode network, showed decreased positive connectivity. Correlation analysis indicated that some increased positive functional connectivity was associated with the Self-Rating Depression Scale, Insomnia Severity Index, and Pittsburgh Sleep Quality Index scores. According to our findings, increased and decreased positive connectivities suggest function strengthening and function disinhibition, respectively, which offers a parsimonious explanation for the hyperarousal hypothesis in the level of the whole-brain functional connectivity in patients with insomnia.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 22%
Student > Master 3 17%
Student > Bachelor 2 11%
Unspecified 1 6%
Professor 1 6%
Other 4 22%
Unknown 3 17%
Readers by discipline Count As %
Psychology 4 22%
Neuroscience 3 17%
Agricultural and Biological Sciences 2 11%
Unspecified 1 6%
Chemical Engineering 1 6%
Other 0 0%
Unknown 7 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2017.
All research outputs
#11,132,953
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,944
of 2,120 outputs
Outputs of similar age
#215,954
of 252,689 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#71
of 93 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,689 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.