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Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2017
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Title
Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies
Published in
Neuropsychiatric Disease and Treatment, February 2017
DOI 10.2147/ndt.s126678
Pubmed ID
Authors

Bo Xiao, Shuai Wang, Jianbo Liu, Tiantian Meng, Yuqiong He, Xuerong Luo

Abstract

The localized dysfunction of specialized brain regions in schizophrenia patients and their unaffected relatives has been identified in a large-scale brain network; however, evidence is inconsistent. We aimed to identify abnormalities in the localized connectivity in schizophrenia patients and their relatives by conducting a meta-analysis of regional homogeneity (ReHo) studies. Fourteen studies on resting-state functional magnetic resonance imaging, with 316 schizophrenia patients, 342 healthy controls, and 66 unaffected relatives, were included in the meta-analysis. This analysis was performed using anisotropic effect-size-based signed differential mapping software. Schizophrenia patients showed increased ReHo in right superior frontal gyrus and right superior temporal gyrus, as well as decreased ReHo in left fusiform gyrus, left superior temporal gyrus, left postcentral gyrus, and right precentral gyrus. Unaffected relatives showed decreased ReHo in right insula and right superior temporal gyrus. These results remained widely unchanged in both sensitivity and subgroup analyses. Schizophrenia patients and their unaffected relatives had extensive abnormal localized connectivity in cerebrum, especially in superior temporal gyrus, which were the potential diagnostic markers and expounded the pathophysiological hypothesis for the disorder.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 23%
Student > Bachelor 5 13%
Student > Ph. D. Student 5 13%
Researcher 3 8%
Student > Doctoral Student 2 5%
Other 4 10%
Unknown 11 28%
Readers by discipline Count As %
Medicine and Dentistry 8 21%
Psychology 7 18%
Neuroscience 7 18%
Nursing and Health Professions 2 5%
Sports and Recreations 1 3%
Other 0 0%
Unknown 14 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2017.
All research outputs
#17,289,387
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,901
of 3,131 outputs
Outputs of similar age
#269,848
of 424,972 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#51
of 74 outputs
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