| Title |
Cytokine biomarkers in tear film for primary open-angle glaucoma
|
|---|---|
| Published in |
Clinical Ophthalmology, February 2017
|
| DOI | 10.2147/opth.s125364 |
| Pubmed ID | |
| Authors |
Divakar Gupta, Joanne C. Wen, Janet L Huebner, Sandra Stinnett, Virginia B Kraus, Henry C Tseng, Molly Walsh |
| Abstract |
To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα). Mean concentrations of tear film cytokines were lower in the glaucoma group for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL in POAG; P=0.035) was significantly lower in the tear film of patients with newly diagnosed POAG. Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early POAG. |
Twitter Demographics
The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 23% |
| Researcher | 3 | 10% |
| Other | 3 | 10% |
| Lecturer | 2 | 6% |
| Unspecified | 2 | 6% |
| Other | 7 | 23% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 19% |
| Unspecified | 2 | 6% |
| Engineering | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Other | 3 | 10% |
| Unknown | 10 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2017.
All research outputs
#14,796,471
of 22,955,959 outputs
Outputs from Clinical Ophthalmology
#1,426
of 3,218 outputs
Outputs of similar age
#239,940
of 420,407 outputs
Outputs of similar age from Clinical Ophthalmology
#18
of 32 outputs
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So far Altmetric has tracked 3,218 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
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We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.