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Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4+ immune cells

Overview of attention for article published in International Journal of Nanomedicine, August 2013
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

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35 Dimensions

Readers on

mendeley
55 Mendeley
Title
Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4+ immune cells
Published in
International Journal of Nanomedicine, August 2013
DOI 10.2147/ijn.s46958
Pubmed ID
Authors

Emmanuel Ho, Chen, Dash, Casey Sayre, Neal Davies, Gu, Sidi Yang

Abstract

The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection. The nanomedicine was formulated into a vaginal gel to provide ease in self-administration and to enhance retention within the vaginal tract. SQV-encapsulated nanoparticles (SQV-NPs) were prepared from poly(lactic-co-glycolic acid) (PLGA) and conjugated to antihuman anti-CD4 antibody. Antibody-conjugated SQV-NPs (Ab-SQV-NPs) had an encapsulation efficiency (EE%) of 74.4% + 3.7% and an antibody conjugation efficiency (ACE%) of 80.95% + 1.10%. Over 50% of total loaded SQV was released from NPs over 3 days. NPs were rapidly taken up by Sup-T1 cells, with more than a twofold increase in the intracellular levels of SQV when delivered by Ab-SQV-NPs in comparison to controls 1 hour post-treatment. No cytotoxicity was observed when vaginal epithelial cells were treated for 24 hours with drug-free Ab-NPs (1,000 μg/mL), 1% HEC placebo gel (200 mg/mL), or 1% HEC gel loaded with drug-free Ab-NPs (5 mg NPs/g gel, 200 mg/mL of gel mixture). Overall, we described an intravaginal nanomedicine that is nontoxic and can specifically deliver SQV into CD4(+) immune cells. This platform may demonstrate potential utility in its application as postexposure prophylaxis for the treatment or reduction of HIV infection, but further studies are required.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 22%
Student > Ph. D. Student 10 18%
Researcher 7 13%
Student > Bachelor 5 9%
Student > Postgraduate 3 5%
Other 8 15%
Unknown 10 18%
Readers by discipline Count As %
Medicine and Dentistry 11 20%
Pharmacology, Toxicology and Pharmaceutical Science 7 13%
Agricultural and Biological Sciences 6 11%
Biochemistry, Genetics and Molecular Biology 5 9%
Chemistry 5 9%
Other 9 16%
Unknown 12 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2013.
All research outputs
#12,391,517
of 21,347,688 outputs
Outputs from International Journal of Nanomedicine
#1,258
of 3,566 outputs
Outputs of similar age
#88,263
of 176,934 outputs
Outputs of similar age from International Journal of Nanomedicine
#37
of 103 outputs
Altmetric has tracked 21,347,688 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,566 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,934 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.