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Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review

Overview of attention for article published in Clinical Pharmacology : Advances and Applications, July 2013
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About this Attention Score

  • Among the highest-scoring outputs from this source (#34 of 137)
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
4 tweeters
patent
1 patent

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
46 Mendeley
citeulike
1 CiteULike
Title
Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review
Published in
Clinical Pharmacology : Advances and Applications, July 2013
DOI 10.2147/cpaa.s32434
Pubmed ID
Authors

Andrew Muzyk, Leung, Jessica Brennan, Gagliardi, Rivelli

Abstract

Baclofen, an agonist at the B subunit of gaba-aminobutyric acid receptor, possesses pharmacologic properties that may confer utility for the treatment of alcohol dependence. Research suggests that not only can it be useful in promoting maintenance of alcohol abstinence but also it may play a key role in decreasing alcohol cravings and anxiety often associated with alcohol dependence. To assess the benefit of baclofen for alcohol dependence, a review of the literature was conducted to identify published data investigating this off-label treatment. Four randomized controlled trials to date have been published and were included in this review. Although primary outcomes differ between studies, patients randomized to baclofen experience higher rates of abstinence from alcohol than those taking placebo in two of the trials. Secondary analyses indicate that baclofen is safe in patients with alcohol dependence, including those with moderate to severe liver cirrhosis, and may provide beneficial anxiolytic effects. Despite some positive data, the largest available randomized controlled trial failed to find any differences between baclofen and placebo. In all studies, individuals with severe medical comorbidities, seizure disorders, and psychiatric disorders were excluded from trials, which may limit external validity. In summary, there may be beneficial effects from using baclofen for the treatment of alcohol dependence; however, limited conclusions can be drawn from the small number of studies currently available for review. Larger well-designed trials are needed to further define baclofen's role for the treatment of alcohol dependence.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 4%
United States 1 2%
United Kingdom 1 2%
Unknown 42 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 17%
Student > Master 8 17%
Researcher 7 15%
Other 5 11%
Student > Bachelor 4 9%
Other 9 20%
Unknown 5 11%
Readers by discipline Count As %
Medicine and Dentistry 19 41%
Psychology 8 17%
Pharmacology, Toxicology and Pharmaceutical Science 5 11%
Neuroscience 2 4%
Agricultural and Biological Sciences 2 4%
Other 4 9%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2020.
All research outputs
#4,585,194
of 17,351,915 outputs
Outputs from Clinical Pharmacology : Advances and Applications
#34
of 137 outputs
Outputs of similar age
#41,349
of 166,403 outputs
Outputs of similar age from Clinical Pharmacology : Advances and Applications
#4
of 10 outputs
Altmetric has tracked 17,351,915 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 137 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,403 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.