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Postpartum depression: psychoneuroimmunological underpinnings and treatment

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2013
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Mentioned by

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1 tweeter

Citations

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29 Dimensions

Readers on

mendeley
122 Mendeley
Title
Postpartum depression: psychoneuroimmunological underpinnings and treatment
Published in
Neuropsychiatric Disease and Treatment, February 2013
DOI 10.2147/ndt.s25320
Pubmed ID
Authors

George Anderson, Maes

Abstract

Postpartum depression (PPD) is common, occurring in 10%-15% of women. Due to concerns about teratogenicity of medications in the suckling infant, the treatment of PPD has often been restricted to psychotherapy. We review here the biological underpinnings to PPD, suggesting a powerful role for the tryptophan catabolites, indoleamine 2,3-dixoygenase, serotonin, and autoimmunity in mediating the consequences of immuno-inflammation and oxidative and nitrosative stress. It is suggested that the increased inflammatory potential, the decreases in endogenous anti-inflammatory compounds together with decreased omega-3 poly-unsaturated fatty acids, in the postnatal period cause an inflammatory environment. The latter may result in the utilization of peripheral inflammatory products, especially kynurenine, in driving the central processes producing postnatal depression. The pharmacological treatment of PPD is placed in this context, and recommendations for more refined and safer treatments are made, including the better utilization of the antidepressant, and the anti-inflammatory and antioxidant effects of melatonin.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Spain 2 2%
United States 1 <1%
Uruguay 1 <1%
Unknown 116 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 25 20%
Student > Ph. D. Student 19 16%
Student > Bachelor 12 10%
Student > Doctoral Student 12 10%
Student > Postgraduate 9 7%
Other 31 25%
Unknown 14 11%
Readers by discipline Count As %
Medicine and Dentistry 34 28%
Psychology 20 16%
Neuroscience 11 9%
Nursing and Health Professions 10 8%
Agricultural and Biological Sciences 9 7%
Other 20 16%
Unknown 18 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2013.
All research outputs
#2,740,634
of 3,631,265 outputs
Outputs from Neuropsychiatric Disease and Treatment
#549
of 677 outputs
Outputs of similar age
#65,730
of 87,874 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#68
of 70 outputs
Altmetric has tracked 3,631,265 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 677 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 87,874 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.