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Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis

Overview of attention for article published in International Journal of Nanomedicine, September 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
2 tweeters
patent
2 patents
googleplus
1 Google+ user

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
33 Mendeley
Title
Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
Published in
International Journal of Nanomedicine, September 2013
DOI 10.2147/ijn.s49745
Pubmed ID
Authors

André Chwalibog, Mateusz Wierzbicki, Ewa Sawosz, Marta Grodzik, Anna Hotowy, Marta Prasek, Slawomir Jaworski, Filip Sawosz

Abstract

Carbon nanoparticles, with their high biocompatibility and low toxicity, have recently been considered for biomedical applications, including antiangiogenic therapy. Critical to normal development and tumor formation, angiogenesis is the process of forming capillary blood vessels from preexisting vessels. In the present study, we evaluated the effects of diamond and graphite nanoparticles on the development of chicken embryos, as well as vascularization of the chorioallantoic membrane and heart at the morphological and molecular level. Nanoparticles did not affect either body/heart weight or serum indices of the embryos' health. However, vascularization of the heart and the density of branched vessels were significantly reduced after treatment with diamond nanoparticles and, to a lesser extent, graphite nanoparticles. Application of nanoparticles significantly downregulated gene and protein expression of the proangiogenic basic fibroblast growth factor, indicating that both diamond and graphite nanoparticles inhibit angiogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 15%
Student > Master 5 15%
Researcher 4 12%
Other 4 12%
Student > Doctoral Student 3 9%
Other 6 18%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 36%
Biochemistry, Genetics and Molecular Biology 4 12%
Medicine and Dentistry 4 12%
Chemistry 2 6%
Unspecified 1 3%
Other 4 12%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2019.
All research outputs
#2,537,679
of 15,956,969 outputs
Outputs from International Journal of Nanomedicine
#141
of 2,993 outputs
Outputs of similar age
#26,555
of 164,515 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 106 outputs
Altmetric has tracked 15,956,969 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,993 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,515 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.