Title |
Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
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Published in |
International Journal of Nanomedicine, September 2013
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DOI | 10.2147/ijn.s49745 |
Pubmed ID | |
Authors |
Mateusz Wierzbicki, Ewa Sawosz, Marta Grodzik, Anna Hotowy, Marta Prasek, Sławomir Jaworski, Filip Sawosz, André Chwalibog |
Abstract |
Carbon nanoparticles, with their high biocompatibility and low toxicity, have recently been considered for biomedical applications, including antiangiogenic therapy. Critical to normal development and tumor formation, angiogenesis is the process of forming capillary blood vessels from preexisting vessels. In the present study, we evaluated the effects of diamond and graphite nanoparticles on the development of chicken embryos, as well as vascularization of the chorioallantoic membrane and heart at the morphological and molecular level. Nanoparticles did not affect either body/heart weight or serum indices of the embryos' health. However, vascularization of the heart and the density of branched vessels were significantly reduced after treatment with diamond nanoparticles and, to a lesser extent, graphite nanoparticles. Application of nanoparticles significantly downregulated gene and protein expression of the proangiogenic basic fibroblast growth factor, indicating that both diamond and graphite nanoparticles inhibit angiogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 14% |
Researcher | 5 | 14% |
Student > Master | 5 | 14% |
Other | 4 | 11% |
Student > Bachelor | 3 | 8% |
Other | 6 | 17% |
Unknown | 8 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 33% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Medicine and Dentistry | 4 | 11% |
Chemistry | 2 | 6% |
Environmental Science | 1 | 3% |
Other | 4 | 11% |
Unknown | 8 | 22% |