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Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers

Overview of attention for article published in International Journal of Nanomedicine, July 2013
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Title
Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers
Published in
International Journal of Nanomedicine, July 2013
DOI 10.2147/ijn.s46578
Pubmed ID
Authors

Feng Shi, Yang, Juan Ren, Guo, Du, Nian-ping Feng

Abstract

In the present study, nanostructured lipid carriers (NLCs) were prepared and optimized for the intravenous delivery of β-Elemene (β-E). Aqueous dispersions of NLCs were successfully prepared by high-pressure homogenization method using glycerol monostearate as the solid lipid and a mixture of Maisine 35-1 and Labrafil M1944 CS as the liquid lipid. The results revealed that the morphology of the NLCs was spheroidal. The particle size, zeta potential, and entrapment efficiency (EE) for the optimized formulation were observed as 138.9 nm, -20.2 mV, and 82.11%, respectively. X-ray diffraction analysis revealed the formation of less ordered structures in the inner core of the NLC particles. Moreover, the β-E-loaded NLCs were also less irritating and less toxic compared to Elemene injection. In addition, β-E-NLCs showed a significantly higher bioavailability and anti-tumor efficacy than Elemene injection. Taken together, our data indicate that the β-E-NLCs described in this study are well-suited for the intravenous delivery of β-E.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 8 33%
Student > Doctoral Student 5 21%
Student > Master 3 13%
Researcher 3 13%
Student > Ph. D. Student 2 8%
Other 3 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 29%
Agricultural and Biological Sciences 4 17%
Medicine and Dentistry 4 17%
Chemistry 4 17%
Arts and Humanities 1 4%
Other 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2013.
All research outputs
#2,906,973
of 3,627,006 outputs
Outputs from International Journal of Nanomedicine
#737
of 869 outputs
Outputs of similar age
#73,136
of 91,844 outputs
Outputs of similar age from International Journal of Nanomedicine
#94
of 96 outputs
Altmetric has tracked 3,627,006 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 869 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,844 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.