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Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics

Overview of attention for article published in International Journal of Nanomedicine, July 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
3 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
75 Dimensions

Readers on

mendeley
180 Mendeley
Title
Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics
Published in
International Journal of Nanomedicine, July 2013
DOI 10.2147/ijn.s45429
Pubmed ID
Authors

Jiezhong Chen, Renfu Shao, Xu Zhang, Chen

Abstract

Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. However, metastasized melanoma is difficult to cure. The 5-year survival rates for patients with metastasized melanoma are still below 20%. Metastasized melanoma is currently treated by chemotherapy, targeted therapy, immunotherapy and radiotherapy. The outcome of most of the current therapies is far from optimistic. Although melanoma patients with a mutation in the oncogene v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) have an initially higher positive response rate to targeted therapy, the majority develop acquired drug resistance after 6 months of the therapy. To increase treatment efficacy, early diagnosis, more potent pharmacological agents, and more effective delivery systems are urgently needed. Nanotechnology has been extensively studied for melanoma treatment and diagnosis, to decrease drug resistance, increase therapeutic efficacy, and reduce side effects. In this review, we summarize the recent progress on the development of various nanoparticles for melanoma treatment and diagnosis. Several common nanoparticles, including liposome, polymersomes, dendrimers, carbon-based nanoparticles, and human albumin, have been used to deliver chemotherapeutic agents, and small interfering ribonucleic acids (siRNAs) against signaling molecules have also been tested for the treatment of melanoma. Indeed, several nanoparticle-delivered drugs have been approved by the US Food and Drug Administration and are currently in clinical trials. The application of nanoparticles could produce side effects, which will need to be reduced so that nanoparticle-delivered drugs can be safely applied in the clinical setting.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 <1%
Netherlands 1 <1%
France 1 <1%
United Kingdom 1 <1%
Argentina 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 173 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 21%
Student > Master 30 17%
Student > Bachelor 28 16%
Researcher 17 9%
Student > Doctoral Student 12 7%
Other 28 16%
Unknown 28 16%
Readers by discipline Count As %
Medicine and Dentistry 31 17%
Agricultural and Biological Sciences 28 16%
Biochemistry, Genetics and Molecular Biology 23 13%
Pharmacology, Toxicology and Pharmaceutical Science 20 11%
Chemistry 17 9%
Other 25 14%
Unknown 36 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2015.
All research outputs
#2,892,696
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#230
of 2,456 outputs
Outputs of similar age
#34,487
of 159,554 outputs
Outputs of similar age from International Journal of Nanomedicine
#8
of 97 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,554 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.