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New developments in the treatment of optic neuritis

Overview of attention for article published in Eye and Brain, June 2010
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Citations

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13 Mendeley
Title
New developments in the treatment of optic neuritis
Published in
Eye and Brain, June 2010
DOI 10.2147/eb.s8386
Pubmed ID
Authors

Tom Jenkins

Abstract

Acute optic neuritis (ON) has various etiologies. The most common presentation is inflammatory, demyelinating, idiopathic, or "typical" ON, which may be associated with multiple sclerosis. This must be differentiated from "atypical" causes of ON, which differ in their clinical presentation, natural history, management, and prognosis. Clinical "red flags" for an atypical cause of ON include absent or persistent pain, exudates and hemorrhages on fundoscopy, very severe, bilateral, or progressive visual loss, and failure to recover. In typical ON, steroids shorten the duration of the attack, but do not influence visual outcome. This is in contrast to atypical ON associated with conditions such as sarcoidosis and neuromyelitis optica, which require aggressive immunosuppression and sometimes plasma exchange. The visual prognosis of typical ON is generally good. The prognosis in atypical ON is more variable. New developments aimed at designing better treatments for patients who fail to recover are discussed, focusing on recent research elucidating mechanisms of damage and recovery in ON. Future therapeutic directions may include enhancing repair processes, such as remyelination or adaptive neuroplasticity, or alternative methods of immunomodulation. Pilot studies investigating the safety and proof-of-principle of stem cell treatment are currently underway.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 23%
Researcher 2 15%
Lecturer > Senior Lecturer 2 15%
Student > Postgraduate 2 15%
Student > Master 1 8%
Other 2 15%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 9 69%
Immunology and Microbiology 1 8%
Neuroscience 1 8%
Agricultural and Biological Sciences 1 8%
Unknown 1 8%