Title |
Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer
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Published in |
International Journal of Nanomedicine, September 2013
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DOI | 10.2147/ijn.s45250 |
Pubmed ID | |
Authors |
Bi-Lan Wang, Yong-mei Shen, Qiong-wen Zhang, Yu-li Li, Min Luo, Ze Liu, Yan Li, Zhi-yong Qian, Xiang Gao, Hua-shan Shi |
Abstract |
Systemic administration of chemotherapy for cancer often has toxic side effects, limiting the doses that can be used in its treatment. In this study, we developed methoxy poly(ethylene glycol)-poly(caprolactone) (MPEG-PCL) micelles loaded with curcumin and doxorubicin (Cur-Dox/MPEG-PCL) that were tolerated by recipient mice and had enhanced antitumor effects and fewer side effects. It was shown that these Cur-Dox/MPEG-PCL micelles could release curcumin and doxorubicin slowly in vitro. The long circulation time of MPEG-PCL micelles and the slow rate of release of curcumin and doxorubicin in vivo may help to maintain plasma concentrations of active drug. We also demonstrated that Cur-Dox/MPEG-PCL had improved antitumor effects both in vivo and in vitro. The mechanism by which Cur-Dox/MPEG-PCL micelles inhibit lung cancer might involve increased apoptosis of tumor cells and inhibition of tumor angiogenesis. We found advantages using Cur-Dox/MPEG-PCL micelles in the treatment of cancer, with Cur-Dox/MPEG-PCL achieving better inhibition of LL/2 lung cancer growth in vivo and in vitro. Our study indicates that Cur-Dox/MPEG-PCL micelles may be an effective treatment strategy for cancer in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
France | 1 | 2% |
Unknown | 59 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 21% |
Student > Master | 10 | 16% |
Researcher | 8 | 13% |
Student > Bachelor | 6 | 10% |
Other | 4 | 7% |
Other | 9 | 15% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 11% |
Medicine and Dentistry | 7 | 11% |
Agricultural and Biological Sciences | 7 | 11% |
Chemical Engineering | 3 | 5% |
Other | 15 | 25% |
Unknown | 14 | 23% |