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Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, March 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
27 Mendeley
Title
Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles
Published in
International Journal of Nanomedicine, March 2017
DOI 10.2147/ijn.s132043
Pubmed ID
Authors

Kyoung Mee Kim, Hyun Kyung Lim, Sang Hee Shim, Joohee Jung

Abstract

Chrysin is a flavone that is found in several plants and in honeycomb and possesses various biological activities. However, its low solubility means it has poor bioavailability, which must be resolved to enable its pharmaceutical applications. In the present study, chrysin was incorporated into methoxy poly(ethylene glycol)-β-polycaprolactone nanoparticles (chrysin-NPs) using the oil-in-water technique in order to overcome problems associated with chrysin. The properties of chrysin-NPs were analyzed, and their anticancer effects were investigated in vitro and in vivo. Chrysin-NPs were 77 nm sized (as determined by dynamic laser light scattering) and showed a monodisperse distribution. The zeta potential of chrysin-NPs was -2.22 mV, and they were spherically shaped by cryo-transmission electron microscopy (cryo-TEM). The loading efficiency of chrysin-NPs was 46.96%. Chrysin-NPs retained the cytotoxicity of chrysin in A549 cells. The therapeutic efficacies of chrysin-NPs were compared with those of chrysin in an A549-derived xenograft mouse model. Chrysin-NPs were intravenously injected at a 10 times lower dosage than chrysin 3 times per week (q2d×3/week). However, free chrysin was orally administrated 5 times per week (q1d×5/week). Chrysin-NP-treated group showed significant tumor growth delay, which was similar to that of chrysin-treated group, despite the considerably lower total dosage. These results suggest that the injectable chrysin-NPs enhance therapeutic efficacy in vivo and offer a beneficial formulation for chemotherapy.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 22%
Student > Master 5 19%
Professor > Associate Professor 3 11%
Researcher 2 7%
Student > Doctoral Student 2 7%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 26%
Medicine and Dentistry 4 15%
Biochemistry, Genetics and Molecular Biology 3 11%
Chemical Engineering 1 4%
Immunology and Microbiology 1 4%
Other 2 7%
Unknown 9 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2019.
All research outputs
#4,504,056
of 14,983,043 outputs
Outputs from International Journal of Nanomedicine
#473
of 2,892 outputs
Outputs of similar age
#95,279
of 265,178 outputs
Outputs of similar age from International Journal of Nanomedicine
#11
of 80 outputs
Altmetric has tracked 14,983,043 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,892 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.