Title |
Advances in the proteomic discovery of novel therapeutic targets in cancer
|
---|---|
Published in |
Drug Design, Development and Therapy, October 2013
|
DOI | 10.2147/dddt.s52216 |
Pubmed ID | |
Authors |
Shanchun Guo, Jin Zou, Guangdi Wang |
Abstract |
Proteomic approaches are continuing to make headways in cancer research by helping to elucidate complex signaling networks that underlie tumorigenesis and disease progression. This review describes recent advances made in the proteomic discovery of drug targets for therapeutic development. A variety of technical and methodological advances are overviewed with a critical assessment of challenges and potentials. A number of potential drug targets, such as baculoviral inhibitor of apoptosis protein repeat-containing protein 6, macrophage inhibitory cytokine 1, phosphoglycerate mutase 1, prohibitin 1, fascin, and pyruvate kinase isozyme 2 were identified in the proteomic analysis of drug-resistant cancer cells, drug action, and differential disease state tissues. Future directions for proteomics-based target identification and validation to be more translation efficient are also discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Italy | 1 | 1% |
Unknown | 68 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 23% |
Researcher | 10 | 14% |
Student > Bachelor | 8 | 11% |
Student > Master | 7 | 10% |
Professor > Associate Professor | 5 | 7% |
Other | 15 | 21% |
Unknown | 10 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 24% |
Medicine and Dentistry | 13 | 18% |
Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Engineering | 3 | 4% |
Other | 8 | 11% |
Unknown | 12 | 17% |