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Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics

Overview of attention for article published in International Journal of Nanomedicine, October 2013
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Title
Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics
Published in
International Journal of Nanomedicine, October 2013
DOI 10.2147/ijn.s47956
Pubmed ID
Authors

Weisan Pan, Ma, Fen Chen, Ye, Dong, Xue, Xu, Wenji Zhang, Song, Ai, Zhang

Abstract

The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil) and to investigate the characteristics of the microemulsion. Brucea javanica oil contains oleic acid and linoleic acids that have been shown by animal and human studies to inhibit tumor formation. The microemulsion containing Brucea javanica oil, medium-chain triglyceride, soybean lecithin, Solutol®HS 15, PEG 400, and water was developed for docetaxel intravenous administration. A formulation with higher drug content, lower viscosity, and smaller particle size was developed. The droplet size distribution of the dispersed phase of the optimized microemulsion was 13.5 nm, determined using a dynamic light scattering technique. The small droplet size enabled the microemulsion droplets to escape from uptake and phagocytosis by the reticuloendothelial system and increased the circulation time of the drug. The zeta potential was -41.3 mV. The optimized microemulsion was pale yellow, transparent, and non-opalescent in appearance. The value of the combination index was 0.58, showing that there was a synergistic effect when docetaxel was combined with Brucea javanica oil. After a single intravenous infusion dose (10 mg/kg) in male Sprague Dawley rats, the area under the curve of the microemulsion was higher and the half-time was longer compared with that of docetaxel solution alone, and showed superior pharmacokinetic characteristics. These results indicate that this preparation of docetaxel in emulsion is likely to provide an excellent prospect for clinical tumor treatment.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 25%
Student > Bachelor 5 16%
Student > Master 4 13%
Researcher 2 6%
Lecturer > Senior Lecturer 1 3%
Other 4 13%
Unknown 8 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 19%
Medicine and Dentistry 5 16%
Chemistry 5 16%
Agricultural and Biological Sciences 2 6%
Engineering 2 6%
Other 3 9%
Unknown 9 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2013.
All research outputs
#3,067,148
of 4,507,509 outputs
Outputs from International Journal of Nanomedicine
#808
of 1,146 outputs
Outputs of similar age
#68,661
of 102,197 outputs
Outputs of similar age from International Journal of Nanomedicine
#89
of 97 outputs
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So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.