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Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria

Overview of attention for article published in International Journal of Nanomedicine, April 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
9 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
79 Mendeley
Title
Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
Published in
International Journal of Nanomedicine, April 2017
DOI 10.2147/ijn.s132784
Pubmed ID
Authors

Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee

Abstract

Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. In this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (CNMA) conjugated to the surface of gold nanoparticles (GNPs) to deliver CNMA efficiently and eradicate biofilms of Gram-negative organisms (enterohemorrhagic Escherichia coli O157:H7, and Pseudomonas aeruginosa), Gram positive (methicillin-sensitive Staphylococcus aureus organisms, and methicillin-resistant Staphylococcus aureus) bacteria. CNMA-GNPs containing 0.005% (v/v) of CNMA were found to inhibit biofilm formation efficiently. The distributions of nanoparticles in biofilm cells and their biofilm disruption activities, including distorted cell morphology, were determined by transmission electron microscopy. In addition to their antibiofilm activities, CNMA-GNPs attenuated S. aureus virulence and protected Caenorhabditis elegans (C. elegans) worms. Here, the authors report the antibiofilm effects of CNMA-GNPs and suggest that they could be used to treat pathogenic bacterial infections in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 79 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 16%
Student > Ph. D. Student 11 14%
Researcher 8 10%
Student > Bachelor 8 10%
Other 5 6%
Other 14 18%
Unknown 20 25%
Readers by discipline Count As %
Chemistry 10 13%
Biochemistry, Genetics and Molecular Biology 10 13%
Agricultural and Biological Sciences 8 10%
Pharmacology, Toxicology and Pharmaceutical Science 6 8%
Immunology and Microbiology 6 8%
Other 13 16%
Unknown 26 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2017.
All research outputs
#3,573,915
of 14,123,042 outputs
Outputs from International Journal of Nanomedicine
#275
of 2,747 outputs
Outputs of similar age
#80,665
of 264,430 outputs
Outputs of similar age from International Journal of Nanomedicine
#10
of 78 outputs
Altmetric has tracked 14,123,042 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,747 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,430 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.