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Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen

Overview of attention for article published in International Journal of Nanomedicine, April 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#45 of 3,051)
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

blogs
1 blog
twitter
8 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
37 Mendeley

What is this page?

Summary Blogs Twitter Facebook Wikipedia Dimensions citations
Title
Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
Published in
International Journal of Nanomedicine, April 2017
DOI 10.2147/ijn.s121400
Pubmed ID
28461747
Authors

Tarek Ahmed, Anthony Nash, Kristina Clark, Marion Ghibaudo, Nora de Leeuw, Anne Potter, Richard Stratton, Helen Birch, Ramona Enea Casse, Laurent Bozec

Abstract

The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to the accumulation of advanced glycation end product (AGE) cross-links, on the nanomechanical properties of the collagen fibril using atomic force microscope nano-indentation. An age-related decrease in the Young's modulus of the transverse fibril was observed (from 8.11 to 4.19 GPa in young to old volunteers, respectively, P<0.001). It is proposed that this is due to a change in the fibril density caused by age-related differences in water retention within the fibrils. The new collagen-water interaction mechanism was verified by electronic structure calculations, showing it to be energetically feasible.

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Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Ph. D. Student 6 16%
Student > Bachelor 6 16%
Other 3 8%
Student > Master 3 8%
Other 3 8%
Unknown 7 19%
Readers by discipline Count As %
Medicine and Dentistry 7 19%
Biochemistry, Genetics and Molecular Biology 7 19%
Chemistry 5 14%
Agricultural and Biological Sciences 3 8%
Nursing and Health Professions 3 8%
Other 6 16%
Unknown 6 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2020.
All research outputs
#1,376,627
of 16,713,463 outputs
Outputs from International Journal of Nanomedicine
#45
of 3,051 outputs
Outputs of similar age
#34,367
of 270,505 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 71 outputs
Altmetric has tracked 16,713,463 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,051 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.

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