| Title |
Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
|
|---|---|
| Published in |
International Journal of Nanomedicine, April 2017
|
| DOI | 10.2147/ijn.s121400 |
| Pubmed ID | |
| Authors |
Tarek Ahmed, Anthony Nash, Kristina EN Clark, Marion Ghibaudo, Nora H de Leeuw, Anne Potter, Richard Stratton, Helen L Birch, Ramona Enea Casse, Laurent Bozec |
| Abstract |
The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to the accumulation of advanced glycation end product (AGE) cross-links, on the nanomechanical properties of the collagen fibril using atomic force microscope nano-indentation. An age-related decrease in the Young's modulus of the transverse fibril was observed (from 8.11 to 4.19 GPa in young to old volunteers, respectively, P<0.001). It is proposed that this is due to a change in the fibril density caused by age-related differences in water retention within the fibrils. The new collagen-water interaction mechanism was verified by electronic structure calculations, showing it to be energetically feasible. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 38% |
| Canada | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 50% |
| Members of the public | 3 | 38% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 19% |
| Student > Ph. D. Student | 10 | 16% |
| Student > Bachelor | 9 | 14% |
| Student > Doctoral Student | 3 | 5% |
| Other | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 20 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Chemistry | 6 | 9% |
| Agricultural and Biological Sciences | 4 | 6% |
| Nursing and Health Professions | 3 | 5% |
| Other | 9 | 14% |
| Unknown | 21 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2020.
All research outputs
#2,459,540
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#96
of 4,077 outputs
Outputs of similar age
#44,492
of 324,452 outputs
Outputs of similar age from International Journal of Nanomedicine
#6
of 99 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,077 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.