↓ Skip to main content

Dove Medical Press

Article Metrics

Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments

Overview of attention for article published in Neuropsychiatric Disease and Treatment, April 2017
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
26 Mendeley
Title
Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments
Published in
Neuropsychiatric Disease and Treatment, April 2017
DOI 10.2147/ndt.s127094
Pubmed ID
Authors

Chun-Xiang Jiao, Heng Zhou, Chun-Xian Yang, Chen Ma, Yue-Xiong Yang, Rong-Rong Mao, Lin Xu, Qi-Xin Zhou

Abstract

With respect to the high burden of ischemic stroke and the absence of pharmacological treatment for promoting rehabilitation, promising candidates with specific effects on long-term functional recovery are highly desired. Candidates need reasonable experimental paradigms to evaluate the long-term functional outcome focused on ischemia-induced sensorimotor and memory deficits. "Danshen", a traditional Chinese herb, has long been used to treat coronary and cerebral vascular diseases as well as dementia. Salvianolic acid A (SAA), one of the major active ingredients of Danshen, was demonstrated to be effective in protecting against cerebral ischemic injury. Here, employing an experimental stroke model induced by photothrombosis in the unilateral frontal cortex of rats, we investigated whether SAA has long-term protective effects on ischemia-induced sensorimotor and memory deficits in our behavioral tests. The results indicated that a single SAA treatment improved the cortical ischemia-induced sensorimotor deficits during 15 days' cylinder test period, and alleviated ischemia-induced sustained spatial memory impairments during the 2 months' dependent Morris Water Maze (MWM) tests. In addition, either ischemic injury or SAA treatment did not show any changes compared with sham group in other behavioral tests including rotarod tests, swimming speed in MWM tests, open field tests, elevated plus maze tests, treadmill tests and forced swimming tests. The results reveal that the cognitive deficits are not the results of animal's anxiety or confounding motor impairments. Overall, the present paradigm appears suitable for the preclinical evaluation of the long-term effects of pharmacological treatments on ischemic stroke. Meanwhile, SAA might have therapeutic potential for the treatment of memory deficits associated with ischemic stroke.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 23%
Student > Bachelor 4 15%
Student > Doctoral Student 3 12%
Student > Ph. D. Student 2 8%
Researcher 2 8%
Other 2 8%
Unknown 7 27%
Readers by discipline Count As %
Neuroscience 4 15%
Medicine and Dentistry 4 15%
Psychology 4 15%
Agricultural and Biological Sciences 2 8%
Decision Sciences 1 4%
Other 2 8%
Unknown 9 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2017.
All research outputs
#12,842,703
of 14,537,474 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,007
of 2,487 outputs
Outputs of similar age
#225,203
of 265,072 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#67
of 82 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,072 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.