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Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, May 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

twitter
2 tweeters
facebook
3 Facebook pages

Citations

dimensions_citation
68 Dimensions

Readers on

mendeley
97 Mendeley
Title
Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?
Published in
International Journal of Chronic Obstructive Pulmonary Disease, May 2017
DOI 10.2147/copd.s127802
Pubmed ID
Authors

Stephanie Hobbins, Iain Chapple, Elizabeth Sapey, Robert Stockley

Abstract

COPD is recognized as having a series of comorbidities potentially related to common inflammatory processes. Periodontitis is one of the most common human inflammatory diseases and has previously been associated with COPD in numerous observational studies. As periodontitis and COPD are both chronic, progressive conditions characterized by neutrophilic inflammation with subsequent proteolytic destruction of connective tissue, it has been proposed that they share common pathophysiological processes. The mechanisms proposed to link COPD and periodontitis include mechanical aspiration of oral contents into the respiratory tree, overspill of locally produced inflammatory mediators into the systemic circulation or oral or lung-derived bacteremia activating an acute-phase response and also reactive oxygen species (ROS) and cytokine release by systemic neutrophils at distant sites. Studies of systemic neutrophils in COPD and chronic periodontitis describe altered cellular functions that would predispose to inflammation and tissue destruction both in the lung and in the mouth, again potentially connecting these conditions. However, COPD and periodontitis also share risk factors such as age, chronic tobacco smoke exposure, and social deprivation that are not always considered in observational and interventional studies. Furthermore, studies reporting associations have often utilized differing definitions of both COPD and periodontitis. This article reviews the current available evidence supporting the hypothesis that COPD and inflammatory periodontal disease (periodontitis) could be pathologically associated, including a review of shared inflammatory mechanisms. It highlights the potential limitations of previous studies, in particular, the lack of uniformly applied case definitions for both COPD and periodontitis and poor recognition of shared risk factors. Understanding associations between these conditions may inform why patients with COPD suffer such a burden of comorbid illness and new therapeutic strategies for both the diseases. However, further research is needed to clarify factors that may be directly causal as opposed to confounding relationships.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 97 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 16%
Student > Postgraduate 10 10%
Student > Master 9 9%
Researcher 8 8%
Student > Ph. D. Student 6 6%
Other 22 23%
Unknown 26 27%
Readers by discipline Count As %
Medicine and Dentistry 48 49%
Nursing and Health Professions 4 4%
Biochemistry, Genetics and Molecular Biology 4 4%
Agricultural and Biological Sciences 3 3%
Psychology 3 3%
Other 6 6%
Unknown 29 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2020.
All research outputs
#9,734,653
of 17,606,952 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#952
of 1,992 outputs
Outputs of similar age
#121,907
of 273,124 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#28
of 63 outputs
Altmetric has tracked 17,606,952 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,992 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,124 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.