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The anticancer properties of iron core–gold shell nanoparticles in colorectal cancer cells

Overview of attention for article published in International Journal of Nanomedicine, September 2013
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46 Mendeley
Title
The anticancer properties of iron core–gold shell nanoparticles in colorectal cancer cells
Published in
International Journal of Nanomedicine, September 2013
DOI 10.2147/ijn.s47742
Pubmed ID
Authors

Ya-Na Wu, Wu, Yang, Ratinac, Thordarson, Jahn, Shieh, Braet, Dong-Hwang Chen

Abstract

Previously, iron core-gold shell nanoparticles (Fe@Au) have been shown to possess cancer-preferential cytotoxicity in oral and colorectal cancer (CRC) cells. However, CRC cell lines are less sensitive to Fe@Au treatment when compared with oral cancer cell lines. In this research, Fe@Au are found to decrease the cell viability of CRC cell lines, including Caco-2, HT-29, and SW480, through growth inhibition rather than the induction of cell death. The cytotoxicity induced by Fe@Au in CRC cells uses different subcellular pathways to the mitochondria-mediated autophagy found in Fe@Au-treated oral cancer cells, OECM1. Interestingly, the Caco-2 cell line shows a similar response to OECM1 cells and is thus more sensitive to Fe@Au treatment than the other CRC cell lines studied. We have investigated the underlying cell resistance mechanisms of Fe@Au-treated CRC cells. The resistance of CRC cells to Fe@Au does not result from the total amount of Fe@Au internalized. Instead, the different amounts of Fe and Au internalized appear to determine the different response to treatment with Fe-only nanoparticles in Fe@Au-resistant CRC cells compared with the Fe@Au-sensitive OECM1 cells. The only moderately cytotoxic effect of Fe@Au nanoparticles on CRC cells, when compared to the highly sensitive OECM1 cells, appears to arise from the CRC cells' relative insensitivity to Fe, as is demonstrated by our Fe-only treatments. This is a surprising outcome, given that Fe has thus far been considered to be the "active" component of Fe@Au nanoparticles. Instead, we have found that the Au coatings, previously considered only as a passivating coating to protect the Fe cores from oxidation, significantly enhance the cytotoxicity of Fe@Au in certain CRC cells. Therefore, we conclude that both the Fe and Au in these core-shell nanoparticles are essential for the anticancer properties observed in CRC cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Japan 1 2%
France 1 2%
Unknown 42 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 26%
Student > Bachelor 6 13%
Student > Doctoral Student 5 11%
Student > Master 5 11%
Researcher 4 9%
Other 8 17%
Unknown 6 13%
Readers by discipline Count As %
Medicine and Dentistry 7 15%
Agricultural and Biological Sciences 7 15%
Chemistry 7 15%
Biochemistry, Genetics and Molecular Biology 3 7%
Materials Science 2 4%
Other 7 15%
Unknown 13 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2013.
All research outputs
#9,957,211
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#1,921
of 2,456 outputs
Outputs of similar age
#157,229
of 230,820 outputs
Outputs of similar age from International Journal of Nanomedicine
#108
of 124 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,820 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.